Projects per year
Abstract
Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.
Original language | English |
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Article number | e199577 |
Number of pages | 14 |
Journal | Development |
Volume | 148 |
Issue number | 17 |
DOIs | |
Publication status | Published - Sept 2021 |
Keywords
- Endometrium
- Extracellular vesicle
- Menstrual fluid
- Menstruation
- Parturition
- Re-epithelialization
- Regeneration
- Scar-free repair
- Stem/progenitor cells
Projects
- 2 Finished
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Translating Endometrial Stem/Progenitor Cell Discoveries to Transform Women's and Girls' Gynaecological Health Outcomes
Gargett, C. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
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Reappraisal of the mechanisms underlying implantation success or failure
Salamonsen, L., Greening, D. W., Evans, J., Simpson, R. J., Catt, S. & Vollenhoven, B.
1/01/18 → 30/06/21
Project: Research