Cyclical endometrial repair and regeneration

Lois A. Salamonsen, Jennifer C. Hutchison, Caroline E. Gargett

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.

Original languageEnglish
Article numbere199577
Number of pages14
JournalDevelopment
Volume148
Issue number17
DOIs
Publication statusPublished - Sep 2021

Keywords

  • Endometrium
  • Extracellular vesicle
  • Menstrual fluid
  • Menstruation
  • Parturition
  • Re-epithelialization
  • Regeneration
  • Scar-free repair
  • Stem/progenitor cells

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