Cyclical endometrial repair and regeneration

Lois A. Salamonsen; Jennifer C. Hutchison; Caroline E. Gargett

doi:10.1242/DEV.199577

Cyclical endometrial repair and regeneration

Lois A. Salamonsen, Jennifer C. Hutchison, Caroline E. Gargett

Research output: Contribution to journal › Review Article › Research › peer-review

55 Citations (Scopus)

Abstract

Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.

Original language	English
Article number	e199577
Number of pages	14
Journal	Development
Volume	148
Issue number	17
DOIs	https://doi.org/10.1242/DEV.199577
Publication status	Published - Sept 2021

Keywords

Endometrium
Extracellular vesicle
Menstrual fluid
Menstruation
Parturition
Re-epithelialization
Regeneration
Scar-free repair
Stem/progenitor cells

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10.1242/DEV.199577

Cite this

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title = "Cyclical endometrial repair and regeneration",

abstract = "Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.",

keywords = "Endometrium, Extracellular vesicle, Menstrual fluid, Menstruation, Parturition, Re-epithelialization, Regeneration, Scar-free repair, Stem/progenitor cells",

author = "Salamonsen, {Lois A.} and Hutchison, {Jennifer C.} and Gargett, {Caroline E.}",

note = "Funding Information: Research at the Hudson Institute of Medical Research is funded in part by State Government of Victoria infrastructure support program. The authors acknowledge grants from the Australian National Health and Medical Research Council to C.E.G. (Investigator Fellowship #1173882) and L.A.S. (Project grant #1139489), and the provision of a Department of Education, Skills and Employment, Australian Government Research Training Program (RTP) scholarship to J.C.H. Publisher Copyright: {\textcopyright} 2021 Company of Biologists Ltd. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = sep,

doi = "10.1242/DEV.199577",

language = "English",

volume = "148",

journal = "Development",

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publisher = "The Company of Biologists",

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AU - Salamonsen, Lois A.

AU - Hutchison, Jennifer C.

AU - Gargett, Caroline E.

N1 - Funding Information: Research at the Hudson Institute of Medical Research is funded in part by State Government of Victoria infrastructure support program. The authors acknowledge grants from the Australian National Health and Medical Research Council to C.E.G. (Investigator Fellowship #1173882) and L.A.S. (Project grant #1139489), and the provision of a Department of Education, Skills and Employment, Australian Government Research Training Program (RTP) scholarship to J.C.H. Publisher Copyright: © 2021 Company of Biologists Ltd. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9

Y1 - 2021/9

N2 - Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.

AB - Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.

KW - Endometrium

KW - Extracellular vesicle

KW - Menstrual fluid

KW - Menstruation

KW - Parturition

KW - Re-epithelialization

KW - Regeneration

KW - Scar-free repair

KW - Stem/progenitor cells

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U2 - 10.1242/DEV.199577

DO - 10.1242/DEV.199577

M3 - Review Article

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AN - SCOPUS:85115323986

SN - 0950-1991

VL - 148

JO - Development

JF - Development

IS - 17

M1 - e199577

ER -

Cyclical endometrial repair and regeneration

Abstract

Keywords

Access to Document

Other files and links

Translating Endometrial Stem/Progenitor Cell Discoveries to Transform Women's and Girls' Gynaecological Health Outcomes

Reappraisal of the mechanisms underlying implantation success or failure

Cite this

Cyclical endometrial repair and regeneration

Abstract

Keywords

Access to Document

Other files and links

Projects

Translating Endometrial Stem/Progenitor Cell Discoveries to Transform Women's and Girls' Gynaecological Health Outcomes

Reappraisal of the mechanisms underlying implantation success or failure

Cite this