Cyclic AMP signaling in pancreatic islets

Brian Furman, Wee Kiat Ong, Nigel J. Pyne

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

65 Citations (Scopus)

Abstract

Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.

Original languageEnglish
Title of host publicationThe Islets of Langerhans
EditorsMd Shahidul Islam
Place of PublicationNetherlands
PublisherSpringer
Chapter13
Pages281-304
Number of pages24
ISBN (Electronic)9789048132713
ISBN (Print)9789048132706
DOIs
Publication statusPublished - 2010
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume654
ISSN (Print)0065-2598

Keywords

  • Adenylyl cyclase
  • Cyclic AMP
  • Epac
  • GLP-1
  • Insulin secretion
  • Phosphodiesterase
  • Protein kinase A

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