CXCR3(+)CCR5(+) T cells and autoimmune diseases: guilty as charged?

    Research output: Contribution to journalArticleOther

    12 Citations (Scopus)

    Abstract

    Prior to the 1990s, genetic analyses indicated that many autoimmune diseases are driven by T cell responses; however, the identity of the pathogenic T cell populations responsible for dysfunctional autoimmune responses remained unclear. Some 20 years ago, the discovery of numerous chemokines and their receptors along with the development of specific mAbs to these provided a distinct advance. These new tools revealed a remarkable dichotomy and disclosed that some chemokine receptors guided the constitutive migration of T cells through lymphoid tissues, whereas others, such as CCR5 and CXCR3, guided effector and memory T cell migration to inflammatory lesions. These T cell markers enabled a new understanding of immune responses and the types of T cells involved in different inflammatory reactions.
    Original languageEnglish
    Pages (from-to)3682 - 3684
    Number of pages3
    JournalJournal of Clinical Investigation
    Volume124
    Issue number9
    DOIs
    Publication statusPublished - 2014

    Cite this

    @article{692f1e1410364ba396a42d13fb1f83f5,
    title = "CXCR3(+)CCR5(+) T cells and autoimmune diseases: guilty as charged?",
    abstract = "Prior to the 1990s, genetic analyses indicated that many autoimmune diseases are driven by T cell responses; however, the identity of the pathogenic T cell populations responsible for dysfunctional autoimmune responses remained unclear. Some 20 years ago, the discovery of numerous chemokines and their receptors along with the development of specific mAbs to these provided a distinct advance. These new tools revealed a remarkable dichotomy and disclosed that some chemokine receptors guided the constitutive migration of T cells through lymphoid tissues, whereas others, such as CCR5 and CXCR3, guided effector and memory T cell migration to inflammatory lesions. These T cell markers enabled a new understanding of immune responses and the types of T cells involved in different inflammatory reactions.",
    author = "Mackay, {Charles Reay}",
    year = "2014",
    doi = "10.1172/JCI77837",
    language = "English",
    volume = "124",
    pages = "3682 -- 3684",
    journal = "Journal of Clinical Investigation",
    issn = "0021-9738",
    publisher = "American Society for Clinical Investigation",
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    }

    CXCR3(+)CCR5(+) T cells and autoimmune diseases: guilty as charged? / Mackay, Charles Reay.

    In: Journal of Clinical Investigation, Vol. 124, No. 9, 2014, p. 3682 - 3684.

    Research output: Contribution to journalArticleOther

    TY - JOUR

    T1 - CXCR3(+)CCR5(+) T cells and autoimmune diseases: guilty as charged?

    AU - Mackay, Charles Reay

    PY - 2014

    Y1 - 2014

    N2 - Prior to the 1990s, genetic analyses indicated that many autoimmune diseases are driven by T cell responses; however, the identity of the pathogenic T cell populations responsible for dysfunctional autoimmune responses remained unclear. Some 20 years ago, the discovery of numerous chemokines and their receptors along with the development of specific mAbs to these provided a distinct advance. These new tools revealed a remarkable dichotomy and disclosed that some chemokine receptors guided the constitutive migration of T cells through lymphoid tissues, whereas others, such as CCR5 and CXCR3, guided effector and memory T cell migration to inflammatory lesions. These T cell markers enabled a new understanding of immune responses and the types of T cells involved in different inflammatory reactions.

    AB - Prior to the 1990s, genetic analyses indicated that many autoimmune diseases are driven by T cell responses; however, the identity of the pathogenic T cell populations responsible for dysfunctional autoimmune responses remained unclear. Some 20 years ago, the discovery of numerous chemokines and their receptors along with the development of specific mAbs to these provided a distinct advance. These new tools revealed a remarkable dichotomy and disclosed that some chemokine receptors guided the constitutive migration of T cells through lymphoid tissues, whereas others, such as CCR5 and CXCR3, guided effector and memory T cell migration to inflammatory lesions. These T cell markers enabled a new understanding of immune responses and the types of T cells involved in different inflammatory reactions.

    UR - http://www.ncbi.nlm.nih.gov/pubmed/25180533

    U2 - 10.1172/JCI77837

    DO - 10.1172/JCI77837

    M3 - Article

    VL - 124

    SP - 3682

    EP - 3684

    JO - Journal of Clinical Investigation

    JF - Journal of Clinical Investigation

    SN - 0021-9738

    IS - 9

    ER -