Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance

Justine D. Mintern, Carole Guillonneau, Francis R. Carbone, Peter C. Doherty, Stephen J. Turner

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

CTL express lytic proteins that mediate the cytolysis of virus-infected cells. In this study, cytolytic transcriptional profiles were determined for individual CTL responding to influenza A virus and HSV-1. During acute infection, influenza-specific CTL in the spleen and respiratory airways displayed highly activated cytolytic profiles, as did HSV-1-specific CTL localized in the spleen, skin, and dorsal root ganglia (DRG). In contrast, memory CTL dramatically down-regulated cytolytic molecule transcription. This occurred for both lymphoid (spleen) and tissue-resident (skin and/or lung) memory CTL. In contrast, HSV-1-specific CTL localized in the dorsal root ganglia in the presence latent HSV-1 Ag did not down-regulate cytolytic molecule transcription. Therefore, both lymphoid and tissue-resident memory CTL down-regulate cytolytic molecule transcription following virus clearance unless localized Ag is present.

Original languageEnglish
Pages (from-to)7220-7224
Number of pages5
JournalJournal of Immunology
Volume179
Issue number11
DOIs
Publication statusPublished - 1 Dec 2007
Externally publishedYes

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