TY - JOUR
T1 - Cutting edge
T2 - Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance
AU - Mintern, Justine D.
AU - Guillonneau, Carole
AU - Carbone, Francis R.
AU - Doherty, Peter C.
AU - Turner, Stephen J.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - CTL express lytic proteins that mediate the cytolysis of virus-infected cells. In this study, cytolytic transcriptional profiles were determined for individual CTL responding to influenza A virus and HSV-1. During acute infection, influenza-specific CTL in the spleen and respiratory airways displayed highly activated cytolytic profiles, as did HSV-1-specific CTL localized in the spleen, skin, and dorsal root ganglia (DRG). In contrast, memory CTL dramatically down-regulated cytolytic molecule transcription. This occurred for both lymphoid (spleen) and tissue-resident (skin and/or lung) memory CTL. In contrast, HSV-1-specific CTL localized in the dorsal root ganglia in the presence latent HSV-1 Ag did not down-regulate cytolytic molecule transcription. Therefore, both lymphoid and tissue-resident memory CTL down-regulate cytolytic molecule transcription following virus clearance unless localized Ag is present.
AB - CTL express lytic proteins that mediate the cytolysis of virus-infected cells. In this study, cytolytic transcriptional profiles were determined for individual CTL responding to influenza A virus and HSV-1. During acute infection, influenza-specific CTL in the spleen and respiratory airways displayed highly activated cytolytic profiles, as did HSV-1-specific CTL localized in the spleen, skin, and dorsal root ganglia (DRG). In contrast, memory CTL dramatically down-regulated cytolytic molecule transcription. This occurred for both lymphoid (spleen) and tissue-resident (skin and/or lung) memory CTL. In contrast, HSV-1-specific CTL localized in the dorsal root ganglia in the presence latent HSV-1 Ag did not down-regulate cytolytic molecule transcription. Therefore, both lymphoid and tissue-resident memory CTL down-regulate cytolytic molecule transcription following virus clearance unless localized Ag is present.
UR - http://www.scopus.com/inward/record.url?scp=38849161553&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.179.11.7220
DO - 10.4049/jimmunol.179.11.7220
M3 - Article
C2 - 18025163
AN - SCOPUS:38849161553
VL - 179
SP - 7220
EP - 7224
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 11
ER -