Cutting edge: Pulmonary Legionella pneumophila is controlled by plasmacytoid dendritic cells but not type I IFN

Desmond KY Ang, Claire VL Oates, Ralf Schuelein, Michelle Louise Kelly, Fiona Margaret Sansom, Dorothee Bourges, Louis Boon, Paul John Hertzog, Elizabeth Louise Hartland, Ian R van Driel

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Plasmacytoid dendritic cells (pDCs) are well known as the major cell type that secretes type I IFN in response to viral infections. Their role in combating other classes of infectious organisms, including bacteria, and their mechanisms of action are poorly understood. We have found that pDCs play a significant role in the acute response to the intracellular bacterial pathogen Legionella pneumophila. pDCs were rapidly recruited to the lungs of L. pneumophila-infected mice, and depletion of pDCs resulted in increased bacterial load. The ability of pDCs to combat infection did not require type I IFN. This study points to an unappreciated role for pDCs in combating bacterial infections and indicates a novel mechanism of action for this cell type.
Original languageEnglish
Pages (from-to)5429 - 5433
Number of pages5
JournalJournal of Immunology
Volume184
Issue number10
DOIs
Publication statusPublished - 2010

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