Cutting edge: Membrane nanotubes in vivo: A feature of MHC class II + cells in the mouse cornea

Holly R Chinnery, Eric Pearlman, Paul G McMenamin

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188 Citations (Scopus)


Membrane nanotubes are a recently discovered form of cellular protrusion between two or more cells whose functions include cell communication, environmental sampling, and protein transfer. Although clearly demonstrated in vitro, evidence of the existence of membrane nanotubes in mammalian tissues in vivo has until now been lacking. Confocal microscopy of whole-mount corneas from wild-type, enhanced GFP chimeric mice, and Cx3cr1(gfp) transgenic mice revealed long (>300 microm) and fine (
Original languageEnglish
Pages (from-to)5779 - 5783
Number of pages5
JournalJournal of Immunology
Issue number9
Publication statusPublished - 2008
Externally publishedYes

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