Cutting edge issues in autoimmune gastritis

Ban-Hock Toh, Christopher Chan, Frank Alderuccio

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Autoimmune gastritis is the outcome of a pathological CD4 T cell-mediated autoimmune response directed against the gastric H/K-ATPase. Silent initially, the gastric lesion becomes manifest in humans by the development of megaloblastic pernicious anemia arising from vitamin B12 deficiency. Cutting edge issues in this disease relate to its epidemiology, immunogenetics, a role for Helicobacter pylori as an infective trigger through molecular mimicry, its immunopathogenesis, associated organ-specific autoimmune diseases, laboratory diagnosis, and approaches to curative therapy.
Original languageEnglish
Pages (from-to)269 - 278
Number of pages10
JournalClinical Reviews in Allergy and Immunology
Publication statusPublished - 2012

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