Current view from alzheimer disease to type 2 diabetes mellitus

Mahmood Rasool; Arif Malik; Aamer M. Qazi; Ishfaq A. Sheikh; Abdul Manan; Sumaira Shaheen; Mahmood H. Qazi; Adeel G. Chaudhary; Adel M. Abuzenadah; Muhammad Asif; Mohammed H. Alqahtani; Zafar Iqbal; Munvar M. Shaik; Siew H. Gan; Mohammad A. Kamal

doi:10.2174/18715273113126660167

Current view from alzheimer disease to type 2 diabetes mellitus

Mahmood Rasool
, Arif Malik
, Aamer M. Qazi
, Ishfaq A. Sheikh
, Abdul Manan
, Sumaira Shaheen
, Mahmood H. Qazi
, Adeel G. Chaudhary
, Adel M. Abuzenadah
, Muhammad Asif
, Mohammed H. Alqahtani
, Zafar Iqbal
, Munvar M. Shaik
, Siew H. Gan
, Mohammad A. Kamal

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that leads to memory problems. It has been associated with type 2 diabetes mellitus at both the molecular and biochemical level. Pancreatic cells have molecular similarities to the brain at the transcriptomic and proteomic levels. Several genes have been reported to be responsible for both AD and diabetes. Currently, no proper treatment is available but various therapeutic approaches are utilized worldwide for the management of these disorders and may be nanoparticles and herbal treatment of Bacopa monnieri will make promise for the treatment of AD in future. The formation of amyloids in neurons and the formation of amylin in pancreatic cells are potential links between these two disorders, which can be silent killers.

Original language	English
Pages (from-to)	533-542
Number of pages	10
Journal	CNS & Neurological Disorders - Drug Targets
Volume	13
Issue number	3
DOIs	https://doi.org/10.2174/18715273113126660167
Publication status	Published - 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Amyloid
Neurodegenerative
Pancreatic cells
Type 2 diabetes mellitus

Access to Document

10.2174/18715273113126660167

Cite this

Rasool, M., Malik, A., Qazi, A. M., Sheikh, I. A., Manan, A., Shaheen, S., Qazi, M. H., Chaudhary, A. G., Abuzenadah, A. M., Asif, M., Alqahtani, M. H., Iqbal, Z., Shaik, M. M., Gan, S. H., & Kamal, M. A. (2014). Current view from alzheimer disease to type 2 diabetes mellitus. CNS & Neurological Disorders - Drug Targets, 13(3), 533-542. https://doi.org/10.2174/18715273113126660167

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title = "Current view from alzheimer disease to type 2 diabetes mellitus",

abstract = "Alzheimer's disease (AD) is a neurodegenerative disorder that leads to memory problems. It has been associated with type 2 diabetes mellitus at both the molecular and biochemical level. Pancreatic cells have molecular similarities to the brain at the transcriptomic and proteomic levels. Several genes have been reported to be responsible for both AD and diabetes. Currently, no proper treatment is available but various therapeutic approaches are utilized worldwide for the management of these disorders and may be nanoparticles and herbal treatment of Bacopa monnieri will make promise for the treatment of AD in future. The formation of amyloids in neurons and the formation of amylin in pancreatic cells are potential links between these two disorders, which can be silent killers.",

keywords = "Amyloid, Neurodegenerative, Pancreatic cells, Type 2 diabetes mellitus",

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AU - Rasool, Mahmood

AU - Malik, Arif

AU - Qazi, Aamer M.

AU - Sheikh, Ishfaq A.

AU - Manan, Abdul

AU - Shaheen, Sumaira

AU - Qazi, Mahmood H.

AU - Chaudhary, Adeel G.

AU - Abuzenadah, Adel M.

AU - Asif, Muhammad

AU - Alqahtani, Mohammed H.

AU - Iqbal, Zafar

AU - Shaik, Munvar M.

AU - Gan, Siew H.

AU - Kamal, Mohammad A.

PY - 2014

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AB - Alzheimer's disease (AD) is a neurodegenerative disorder that leads to memory problems. It has been associated with type 2 diabetes mellitus at both the molecular and biochemical level. Pancreatic cells have molecular similarities to the brain at the transcriptomic and proteomic levels. Several genes have been reported to be responsible for both AD and diabetes. Currently, no proper treatment is available but various therapeutic approaches are utilized worldwide for the management of these disorders and may be nanoparticles and herbal treatment of Bacopa monnieri will make promise for the treatment of AD in future. The formation of amyloids in neurons and the formation of amylin in pancreatic cells are potential links between these two disorders, which can be silent killers.

KW - Amyloid

KW - Neurodegenerative

KW - Pancreatic cells

KW - Type 2 diabetes mellitus

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M3 - Article

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AN - SCOPUS:84904467676

SN - 1871-5273

VL - 13

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JO - CNS & Neurological Disorders - Drug Targets

JF - CNS & Neurological Disorders - Drug Targets

IS - 3

ER -

Current view from alzheimer disease to type 2 diabetes mellitus

Abstract

UN SDGs

Keywords

Access to Document

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