Current Utility and Future Applications of ctDNA in Colorectal Cancer

Daphne Day, Sophia Frentzas, Cameron Ashley Naidu, Eva Segelov, Maja Green

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Research


Circulating tumour DNA (ctDNA) shows promise as a minimally invasive
biomarker with a myriad of emerging applications including early detection
and diagnosis, monitoring of disease and treatment efficacy, and identification
of actionable alterations to guide treatment. The potential utility of ctDNA in
colorectal carcinoma (CRC) is of particular interest given the limitations of current radiographic imaging and blood-based tumour markers in detecting disease and evaluating therapeutic benefit. While ctDNA has yet to demonstrate clinical utility in CRC, a growing body of research highlights the potential of these novel biomarkers. This chapter provides an overview of the current evidence for employing ctDNA in CRC as well as previewing the future directions that these exciting technologies may take.
Original languageEnglish
Title of host publicationAdvances in the Molecular Understanding of Colorectal Cancer
EditorsEva Segelov
Number of pages24
ISBN (Electronic)9781789850604
ISBN (Print)9781789850598
Publication statusPublished - 6 Feb 2019

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