Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis

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Abstract

Inflammation, in addition to high cholesterol is a major factor contributing to atherosclerosis-associated adverse cardiovascular events. Thus, there is a pressing need for additional therapeutic strategies to reduce inflammation, by targeting immune cells and cytokines. Here we review B cell subsets and adventitial and intimal B cells in atherosclerosis development and discuss potential B cell-targeted anti-inflammatory therapies for atherosclerosis.
Original languageEnglish
Pages (from-to)373 - 379
Number of pages7
JournalCurrent Opinion in Lipidology
Volume22
Issue number5
DOIs
Publication statusPublished - 2011

Cite this

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title = "Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis",
abstract = "Inflammation, in addition to high cholesterol is a major factor contributing to atherosclerosis-associated adverse cardiovascular events. Thus, there is a pressing need for additional therapeutic strategies to reduce inflammation, by targeting immune cells and cytokines. Here we review B cell subsets and adventitial and intimal B cells in atherosclerosis development and discuss potential B cell-targeted anti-inflammatory therapies for atherosclerosis.",
author = "Tin Kyaw and Peter Tipping and Ban-Hock Toh and Alexander Bobik",
year = "2011",
doi = "10.1097/MOL.0b013e32834adaf3",
language = "English",
volume = "22",
pages = "373 -- 379",
journal = "Current Opinion in Lipidology",
issn = "0957-9672",
publisher = "Lippincott Williams & Wilkins",
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TY - JOUR

T1 - Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis

AU - Kyaw, Tin

AU - Tipping, Peter

AU - Toh, Ban-Hock

AU - Bobik, Alexander

PY - 2011

Y1 - 2011

N2 - Inflammation, in addition to high cholesterol is a major factor contributing to atherosclerosis-associated adverse cardiovascular events. Thus, there is a pressing need for additional therapeutic strategies to reduce inflammation, by targeting immune cells and cytokines. Here we review B cell subsets and adventitial and intimal B cells in atherosclerosis development and discuss potential B cell-targeted anti-inflammatory therapies for atherosclerosis.

AB - Inflammation, in addition to high cholesterol is a major factor contributing to atherosclerosis-associated adverse cardiovascular events. Thus, there is a pressing need for additional therapeutic strategies to reduce inflammation, by targeting immune cells and cytokines. Here we review B cell subsets and adventitial and intimal B cells in atherosclerosis development and discuss potential B cell-targeted anti-inflammatory therapies for atherosclerosis.

UR - http://www.ncbi.nlm.nih.gov/pubmed/21881498

U2 - 10.1097/MOL.0b013e32834adaf3

DO - 10.1097/MOL.0b013e32834adaf3

M3 - Article

VL - 22

SP - 373

EP - 379

JO - Current Opinion in Lipidology

JF - Current Opinion in Lipidology

SN - 0957-9672

IS - 5

ER -