Current perspectives in Set7 mediated stem cell differentiation

Nazanin Karimnia, Haloom Rafehi, Natasha K. Tuano, Mark Ziemann, Harikrishnan K.N., Jun Okabe, Assam El-Osta

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Abstract

Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.

Original languageEnglish
Article number2040014
Number of pages8
JournalNon-Coding RNA
Volume2
Issue number4
DOIs
Publication statusPublished - 4 Dec 2016

Keywords

  • Histone
  • Non-coding RNA
  • Non-histone protein
  • Set7
  • Stem cell differentiation

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