Current challenges in the prevention and management of post-thrombotic syndrome—towards improved prevention

Julie Wang, Elise Smeath, Hui Yin Lim, Harshal Nandurkar, Hong Kuan Kok, Prahlad Ho

Research output: Contribution to journalReview ArticleResearchpeer-review


Post-thrombotic syndrome (PTS) is a common and potentially debilitating complication of deep vein thrombosis (DVT), affecting up to 50% of DVT patients. The consequence of this chronic condition includes reduced quality of life, increased use of the healthcare system and decreased productivity. The societal impact of this condition is projected to increase, given our ageing population and increased burden of thrombotic diseases. Despite significant recent advances in our understanding of PTS, many unanswered questions remain. Currently, there are few effective and proven options for established PTS; hence, the emphasis should be on instituting effective prevention to reduce the progression to PTS. Effective anticoagulation lowers the risk of PTS, with direct oral anticoagulants appearing to outperform vitamin-K antagonists. However, the evidence for elastic compression stockings and endovascular thrombolysis or thrombectomy techniques remains unclear. Accurate identification of individuals at high risk of developing PTS may also improve the targeting of preventative interventions. This review will examine the current body of evidence regarding PTS, with a focus on preventative strategies as well as novel biomarkers.

Original languageEnglish
Number of pages21
JournalInternational Journal of Hematology
Publication statusAccepted/In press - 2023


  • Biomarkers
  • Deep vein thrombosis
  • Post-thrombotic syndrome

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