Current and emerging antiviral treatments for hepatitis C infection

Joseph S Doyle, Esther J Aspinall, Danny Yearn Hian Liew, Alexander J Thompson, Margaret Elena Hellard

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Abstract

Newly licensed direct acting antivirals for hepatitis C virus HCV are able to cure up to 75 of patients chronically infected with genotype-1 infection, which is the predominant HCV strain in Europe and North America. Emerging antiviral therapies promise further increases in virological response, as well as improved tolerability, reduced duration of therapy, and will potentially eliminate the need for interferon use. This review highlights the main therapeutic agents used in current standard of care, including telaprevir and boceprevir. It goes on to evaluate the mechanisms of emerging drugs, their stage of development and response rates seen in research to date. Finally, it projects into the not too distant future to consider treatment strategies involving combinations of agents and interferon-free therapies, and in which patients they might prove most successful.
Original languageEnglish
Pages (from-to)931 - 943
Number of pages13
JournalBritish Journal of Clinical Pharmacology
Volume75
Issue number4
DOIs
Publication statusPublished - 2013

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