Current advances in noncoding RNA relevant to epigenetic mechanisms

Prabhu Mathiyalagan, Waheed Khan, Xiao-Jun Du, Assam El-Osta

Research output: Contribution to journalArticleOtherpeer-review

Abstract

The human genome regulates dynamic patterns of transcript expression and while studies in recent years by the Encyclopedia of DNA Elements (ENCODE) consortium have shown the remarkable complexity of pervasive transcription, it is estimated that less than 2 % of the genome codes for proteins. Multiple lines of experimental evidence now highlight the functional importance of noncoding RNAs (ncRNAs) that serve to control transcription that underlie development and homeostatic control in metazoans. An emerging theme is the modulation of transcription factor binding governed by ncRNA-chromatin interactions. Some of the recent discoveries of contractile function in the heart implicate novel roles for long ncRNAs (lncRNAs), including the primary microRNA-208b (Pri-miR-208b) as well as antisense β-MHC (AS β-MHC). As such, this review will focus on the signaling and regulatory functions of ncRNAs that ensure homeostasis of mammalian myosin motor protein expression and cardiovascular disease.
Original languageEnglish
Pages (from-to)29 - 38
Number of pages10
JournalCurrent Molecular Biology Reports
Volume1
Issue number1
DOIs
Publication statusPublished - Mar 2015

Cite this

@article{15363ecbc3df4caca22b0790669e5b75,
title = "Current advances in noncoding RNA relevant to epigenetic mechanisms",
abstract = "The human genome regulates dynamic patterns of transcript expression and while studies in recent years by the Encyclopedia of DNA Elements (ENCODE) consortium have shown the remarkable complexity of pervasive transcription, it is estimated that less than 2 {\%} of the genome codes for proteins. Multiple lines of experimental evidence now highlight the functional importance of noncoding RNAs (ncRNAs) that serve to control transcription that underlie development and homeostatic control in metazoans. An emerging theme is the modulation of transcription factor binding governed by ncRNA-chromatin interactions. Some of the recent discoveries of contractile function in the heart implicate novel roles for long ncRNAs (lncRNAs), including the primary microRNA-208b (Pri-miR-208b) as well as antisense β-MHC (AS β-MHC). As such, this review will focus on the signaling and regulatory functions of ncRNAs that ensure homeostasis of mammalian myosin motor protein expression and cardiovascular disease.",
author = "Prabhu Mathiyalagan and Waheed Khan and Xiao-Jun Du and Assam El-Osta",
year = "2015",
month = "3",
doi = "10.1007/s40610-015-0004-4",
language = "English",
volume = "1",
pages = "29 -- 38",
journal = "Current Molecular Biology Reports",
issn = "2198-6428",
publisher = "Springer",
number = "1",

}

Current advances in noncoding RNA relevant to epigenetic mechanisms. / Mathiyalagan, Prabhu; Khan, Waheed; Du, Xiao-Jun; El-Osta, Assam.

In: Current Molecular Biology Reports, Vol. 1, No. 1, 03.2015, p. 29 - 38.

Research output: Contribution to journalArticleOtherpeer-review

TY - JOUR

T1 - Current advances in noncoding RNA relevant to epigenetic mechanisms

AU - Mathiyalagan, Prabhu

AU - Khan, Waheed

AU - Du, Xiao-Jun

AU - El-Osta, Assam

PY - 2015/3

Y1 - 2015/3

N2 - The human genome regulates dynamic patterns of transcript expression and while studies in recent years by the Encyclopedia of DNA Elements (ENCODE) consortium have shown the remarkable complexity of pervasive transcription, it is estimated that less than 2 % of the genome codes for proteins. Multiple lines of experimental evidence now highlight the functional importance of noncoding RNAs (ncRNAs) that serve to control transcription that underlie development and homeostatic control in metazoans. An emerging theme is the modulation of transcription factor binding governed by ncRNA-chromatin interactions. Some of the recent discoveries of contractile function in the heart implicate novel roles for long ncRNAs (lncRNAs), including the primary microRNA-208b (Pri-miR-208b) as well as antisense β-MHC (AS β-MHC). As such, this review will focus on the signaling and regulatory functions of ncRNAs that ensure homeostasis of mammalian myosin motor protein expression and cardiovascular disease.

AB - The human genome regulates dynamic patterns of transcript expression and while studies in recent years by the Encyclopedia of DNA Elements (ENCODE) consortium have shown the remarkable complexity of pervasive transcription, it is estimated that less than 2 % of the genome codes for proteins. Multiple lines of experimental evidence now highlight the functional importance of noncoding RNAs (ncRNAs) that serve to control transcription that underlie development and homeostatic control in metazoans. An emerging theme is the modulation of transcription factor binding governed by ncRNA-chromatin interactions. Some of the recent discoveries of contractile function in the heart implicate novel roles for long ncRNAs (lncRNAs), including the primary microRNA-208b (Pri-miR-208b) as well as antisense β-MHC (AS β-MHC). As such, this review will focus on the signaling and regulatory functions of ncRNAs that ensure homeostasis of mammalian myosin motor protein expression and cardiovascular disease.

U2 - 10.1007/s40610-015-0004-4

DO - 10.1007/s40610-015-0004-4

M3 - Article

VL - 1

SP - 29

EP - 38

JO - Current Molecular Biology Reports

JF - Current Molecular Biology Reports

SN - 2198-6428

IS - 1

ER -