Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement

Shanti Narayanasamy, Roger L. Nation, Andrew A. Mahony, M. Lindsay Grayson, Jason C. Kwong, Norelle L. Sherry, Sharmila Khumra, Andrew G. Ellis, Albert G. Frauman, Natasha E. Holmes

Research output: Contribution to journalArticleOther

2 Citations (Scopus)

Abstract

We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.

Original languageEnglish
Article numberofaa572
Number of pages6
JournalOpen Forum Infectious Diseases
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • colistin
  • fosfomycin
  • osteomyelitis
  • therapeutic drug monitoring
  • XDR gram-negative

Cite this