@article{549e7caca9fc46d18e3803f144fc286e,
title = "Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement",
abstract = "We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.",
keywords = "colistin, fosfomycin, osteomyelitis, therapeutic drug monitoring, XDR gram-negative",
author = "Shanti Narayanasamy and Nation, {Roger L.} and Mahony, {Andrew A.} and Grayson, {M. Lindsay} and Kwong, {Jason C.} and Sherry, {Norelle L.} and Sharmila Khumra and Ellis, {Andrew G.} and Frauman, {Albert G.} and Holmes, {Natasha E.}",
note = "Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
day = "1",
doi = "10.1093/ofid/ofaa572",
language = "English",
volume = "8",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "1",
}