Curcumin-containing chitosan nanoparticles as a potential mucoadhesive delivery system to the colon.

Lay Hong Chuah, Nashiru Billa, Clive J. Roberts, Jonathan C. Burley, Sivakumar Manickam

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105 Citations (Scopus)

Abstract

In the present study, we investigate the mucoadhesive characteristics and release of the anticancer agent curcumin, contained in chitosan nanoparticles (CS-NPs). Such a system has potential therapeutic benefits in the treatment of colon cancer through prolonged retention and delivery. The CS-NPs were ionically gelled with tripolyphosphate (TPP) and registered an isoelectric pH of 6.2 (z-average diameter of 214 nm ± 1.0 nm). pH variations around the isoelectric point caused a reduction in CS-NPs electrical charge which correspondingly increased the z-average due to agglomeration. Curcumin release from CS-NPs was slowest at chitosan to TPP weight ratio of 3:1, with a significant retention (36%) at the end of 6 h. Adsorption isotherms of mucin on CS-NPs fitted both the Freundlich and Langmuir models, suggesting a monolayer-limited adsorption on heterogeneous sites with varied affinities. Encapsulated curcumin exerted an influence on the adsorption of mucin due to H-bonding as well as π-π interactions between the phenolic moieties of curcumin and mucin.

Original languageEnglish
Pages (from-to)591-599
Number of pages9
JournalPharmaceutical Development and Technology
Volume18
Issue number3
DOIs
Publication statusPublished - 2013
Externally publishedYes

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