Abstract
CuI facilitated three-component reaction of isatin derivatives, l-proline and terminal alkynes containing an amide or ester functional group. The multi-component reaction (MCR) afforded a faster and practical synthesis of spirooxindole derivatives. A range of novel spirooxindoles were synthesized by using this straightforward and one-pot efficient methodology. A representative compound showed significant inhibition of PDE4B enzyme in vitro and good interactions with this protein in silico.
Original language | English |
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Pages (from-to) | 5448-5452 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 54 |
Issue number | 40 |
DOIs | |
Publication status | Published - 2 Oct 2013 |
Externally published | Yes |
Keywords
- CuI
- MCR
- PDE4B
- Spirooxindole