Projects per year
Abstract
This study aimed to determine the relationship between the apolipoprotein E (APOE) ε4 allele and cerebrospinal fluid (CSF) and neuroimaging biomarkers of Alzheimer's disease, and cognition in cognitively unimpaired (CU) middle-aged adults (n = 82; Mage = 58.2), and in Aβ- CU older adults (n = 71; Mage = 71.8). Aβ- CU middle-aged ε4 carriers showed lower CSF Aβ42 levels, higher levels of CSF total tau (t-tau) and neurofilament light (NfL), and poorer cognitive performance compared to noncarriers (Cohen's d: 0.30–0.56). In Aβ- CU older adults, ε4 carriers also had lower CSF Aβ42 levels and higher levels of CSF t-tau and p-tau181, compared to noncarriers (Cohen's d: 0.65–0.74). In both Aβ- middle-aged and older adults, hippocampal and total brain volume were equivalent between ε4 carriers and noncarriers. In Aβ- CU middle-aged adults, APOE ε4 is associated with decreased levels of Aβ, increased tau and NfL, and poorer cognition. Similar relationships were observed in Aβ- CU older adults. These results have implications for understanding clinicopathological relationships between APOE ε4 and the emergence of cognitive and biomarker abnormalities in Aβ- adults.
Original language | English |
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Pages (from-to) | 209-218 |
Number of pages | 10 |
Journal | Neurobiology of Aging |
Volume | 129 |
DOIs | |
Publication status | Published - Sept 2023 |
Keywords
- Alzheimer's disease
- Amyloid
- Apolipoprotein E
- Cognition
- Phosphorylated tau
Projects
- 2 Finished
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Effects of Poor Sleep on Alzheimer’s Disease Pathogenesis: Extending the Glymphatic Flow Hypothesis
Pase, M., Lim, Y. Y., Naughton, M. & Buckley, R.
National Health and Medical Research Council (NHMRC) (Australia)
4/05/20 → 31/12/24
Project: Research