Crystal structure and mechanism of a DNA (6-4) photolyase

Melanie J. Maul; Thomas R M Barends; Andreas F. Glas; Max J. Cryle; Tatiana Domratcheva; Sabine Schneider; Ilme Schlichting; Thomas Carell

doi:10.1002/anie.200804268

Crystal structure and mechanism of a DNA (6-4) photolyase

Melanie J. Maul, Thomas R M Barends, Andreas F. Glas, Max J. Cryle, Tatiana Domratcheva, Sabine Schneider, Ilme Schlichting, Thomas Carell

Research output: Contribution to journal › Article › Research › peer-review

171 Citations (Scopus)

Abstract

(Figure Presented) Before and after: Crystal structures of the DNA (6-4) photolyase from D. melanogaster-one structure in complex with DNA containing a (6-4) lesion (see picture) and one in which the lesion has been repaired-provide new insight into lesion recognition and repair. The proposed mechanism for light-induced, electron-transfer-based repair of the (6-4) lesion does not proceed via an oxetane intermediate.

Original language	English
Pages (from-to)	10076-10080
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	52
DOIs	https://doi.org/10.1002/anie.200804268
Publication status	Published - 15 Dec 2008
Externally published	Yes

Keywords

DNA damage
DNA repair
Enzymes
Photochemistry
Structure elucidation

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10.1002/anie.200804268

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title = "Crystal structure and mechanism of a DNA (6-4) photolyase",

abstract = "(Figure Presented) Before and after: Crystal structures of the DNA (6-4) photolyase from D. melanogaster-one structure in complex with DNA containing a (6-4) lesion (see picture) and one in which the lesion has been repaired-provide new insight into lesion recognition and repair. The proposed mechanism for light-induced, electron-transfer-based repair of the (6-4) lesion does not proceed via an oxetane intermediate.",

keywords = "DNA damage, DNA repair, Enzymes, Photochemistry, Structure elucidation",

author = "Maul, \{Melanie J.\} and Barends, \{Thomas R M\} and Glas, \{Andreas F.\} and Cryle, \{Max J.\} and Tatiana Domratcheva and Sabine Schneider and Ilme Schlichting and Thomas Carell",

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doi = "10.1002/anie.200804268",

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T1 - Crystal structure and mechanism of a DNA (6-4) photolyase

AU - Maul, Melanie J.

AU - Barends, Thomas R M

AU - Glas, Andreas F.

AU - Cryle, Max J.

AU - Domratcheva, Tatiana

AU - Schneider, Sabine

AU - Schlichting, Ilme

AU - Carell, Thomas

PY - 2008/12/15

Y1 - 2008/12/15

N2 - (Figure Presented) Before and after: Crystal structures of the DNA (6-4) photolyase from D. melanogaster-one structure in complex with DNA containing a (6-4) lesion (see picture) and one in which the lesion has been repaired-provide new insight into lesion recognition and repair. The proposed mechanism for light-induced, electron-transfer-based repair of the (6-4) lesion does not proceed via an oxetane intermediate.

AB - (Figure Presented) Before and after: Crystal structures of the DNA (6-4) photolyase from D. melanogaster-one structure in complex with DNA containing a (6-4) lesion (see picture) and one in which the lesion has been repaired-provide new insight into lesion recognition and repair. The proposed mechanism for light-induced, electron-transfer-based repair of the (6-4) lesion does not proceed via an oxetane intermediate.

KW - DNA damage

KW - DNA repair

KW - Enzymes

KW - Photochemistry

KW - Structure elucidation

UR - https://www.scopus.com/pages/publications/57749084494

U2 - 10.1002/anie.200804268

DO - 10.1002/anie.200804268

M3 - Article

C2 - 18956392

AN - SCOPUS:57749084494

SN - 1433-7851

VL - 47

SP - 10076

EP - 10080

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 52

ER -

Crystal structure and mechanism of a DNA (6-4) photolyase

Abstract

Keywords

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