Crystal structure and mechanism of a DNA (6-4) photolyase

Melanie J. Maul, Thomas R M Barends, Andreas F. Glas, Max J. Cryle, Tatiana Domratcheva, Sabine Schneider, Ilme Schlichting, Thomas Carell

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139 Citations (Scopus)

Abstract

(Figure Presented) Before and after: Crystal structures of the DNA (6-4) photolyase from D. melanogaster-one structure in complex with DNA containing a (6-4) lesion (see picture) and one in which the lesion has been repaired-provide new insight into lesion recognition and repair. The proposed mechanism for light-induced, electron-transfer-based repair of the (6-4) lesion does not proceed via an oxetane intermediate.

Original languageEnglish
Pages (from-to)10076-10080
Number of pages5
JournalAngewandte Chemie - International Edition
Volume47
Issue number52
DOIs
Publication statusPublished - 15 Dec 2008
Externally publishedYes

Keywords

  • DNA damage
  • DNA repair
  • Enzymes
  • Photochemistry
  • Structure elucidation

Cite this

Maul, M. J., Barends, T. R. M., Glas, A. F., Cryle, M. J., Domratcheva, T., Schneider, S., Schlichting, I., & Carell, T. (2008). Crystal structure and mechanism of a DNA (6-4) photolyase. Angewandte Chemie - International Edition, 47(52), 10076-10080. https://doi.org/10.1002/anie.200804268