Cryptococcus gattii infection causing fulminant intracranial hypertension

J. Bromilow, T. Corcoran

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Cryptococcus neoformans variety gattii (C. gattii) causes infection in predominantly immunocompetent individuals. The majority of cases present with headache due to meningitis and its natural history normally follows an indolent course. We report a fatal case of fulminant cryptococcaemia culminating in severe intracranial hypertension due to C. gattii. Such cases of fulminant disease are rare and highlight a number of important therapeutic and diagnostic considerations. We discuss the atypical nature of this patient's illness, the major complications of C. gattii meningitis and the role of computed tomography (CT) in preventing serious sequelae from lumbar puncture. The management of intracranial hypertension (ICH) in critically ill patients is also reviewed.

Original languageEnglish
Pages (from-to)528-531
Number of pages4
JournalBritish Journal of Anaesthesia
Issue number4
Publication statusPublished - 2007
Externally publishedYes


  • Brain, intracranial pressure
  • Coma, aetiology
  • Cryptococcus, physiology
  • Intracranial hypertension
  • Meningitis, cryptococcal

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