Longitudinal modulation of chromatographic bands by using a cryogenic system gives a new way of handling and processing migrating solutes in capillary columns. Whilst trapping of volatile components in cooled devices is a well understood and widely used phenomenon, being able to remobilize the trapped component in the manner described in this article allows a number of new methods to be used during chromatographic analysis. The longitudinally modulated cryogenic system (LMCS) can be placed at the start, end or mid-region of the column, and each of these produces specific benefits according to how the system is employed. Whilst its use in single dimensional analysis is reasonably straightforward, its potential in multidimensional gas chromatography should show great promise. An application describing a robust and easily implemented comprehensive GC method offers the analyst entry into very powerful separation technology, which could very well represent the future approach to complex mixture analysis. Copyright (C) 1999 Elsevier Science B.V.
- Cryogenic solute manipulation
- Longitudinally modulated cryogenic system
- Multidimensional chromatography