Cross-talk between protein synthesis, energy metabolism and autophagy in cancer

Lisa M. Lindqvist, Kristofferson Tandoc, Ivan Topisirovic, Luc Furic

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Translation is a pivotal step in the regulation of gene expression as well as one of the most energy consuming processes in the cell. Dysregulation of translation caused by the aberrant function of upstream signaling pathways and/or perturbations in the expression or function of components of the translation machinery is frequent in cancer. In this review, we discuss emerging findings that highlight hitherto unappreciated aspects of signaling to the translation apparatus with the particular focus on emerging connections between protein synthesis, autophagy and energy homeostasis in cancer.

Original languageEnglish
Pages (from-to)104-111
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume48
DOIs
Publication statusPublished - 1 Feb 2018

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