Cross-talk between F3/contactin and Notch at axoglial interface: a role in oligodendrocyte development

Qi-Dong Hu, Quan-Hong Ma, Gianfranco Gennarini, Zhi-Cheng Xiao

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Abstract

Increasing evidence has shown that the Notch signalling pathway regulates oligodendrogliogenesis. Upon binding to classical Delta/Serrate/Lag-2 ligands, Notch signalling promotes generation of oligodendrocyte precursor cells while inhibiting their further differentiation into myelinating oligodendrocytes. In our recent studies, we have found that two neural cell adhesion molecules, F3/contactin and NB-3 interact with Notch receptors and promote oligodendrocyte development. Remarkably, all these F3 and NB-3/Notch cascade-related events required Deltex1 as the intermediate element. Experiments using several animal models further imply the function of F3/Notch signalling in vivo, which designates Notch signalling as a ligand-dependent, multipotential cascade involved in oligodendrocyte development.
Original languageEnglish
Pages (from-to)25 - 33
Number of pages9
JournalDevelopmental Neuroscience
Volume28
Issue number1-2
DOIs
Publication statusPublished - 2006
Externally publishedYes

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