Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults

the eGFR Study

J. T. Hughes, L. J. Maple-Brown, M. Thomas, P. D. Lawton, A. Sinha, A. Cass, F. Barzi, G. R.D. Jones, G. Jerums, R. J. MacIsaac, K. O'Dea, W. E. Hoy

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To describe the detailed associations of albuminuria among a contemporary cohort of Aboriginal and Torres Strait Islander people to inform strategies for chronic kidney disease prevention and management. Methods: A cross-sectional analysis of Indigenous participants of the eGFR Study. Measures: Clinical, biochemical and anthropometric measures were collected (including body-circumferences, blood pressure (BP); triglycerides, HbA1c, liver function tests, creatinine; urine- microscopic-haem, albumin: creatinine ratio (ACR), prescriptions- angiotensin converting enzyme inhibitor or angiotensin receptor II antagonist (ACEI/ARB). Albuminuria and diabetes were defined by an ACR>3.0 mg/mmol, and HbA1c≥48 mmol/mol or prior history respectively. Waist: hip ratio (WHR), and estimated glomerular filtration rate (eGFR) were calculated. ACR was non-normally distributed; a logarithmic transformation was applied (in base 2), with each unit increase in log2-albuminuria representing a doubling of ACR. Results: 591 participants were assessed (71% Aboriginal, 61.6% female, mean age 45.1 years, BMI 30.2 kg/m2, WHR 0.94, eGFR 99.2 ml/min/1.73m2). The overall prevalence of albuminuria, diabetes, microscopic-haem and ACEI/ARB use was 41.5%, 41.5%, 17.8% and 34.7% respectively; 69.3% of adults with albuminuria and diabetes received an ACEI/ARB. Using multivariable linear regression modelling, the potentially modifiable factors independently associated with log2-albuminuria were microscopic-haem, diabetes, WHR, systolic BP, alkaline phosphatase (all positive) and eGFR (inverse). Conclusion: Albuminuria is associated with diabetes, central obesity and haematuria. High ACEI/ARB prescribing for adults with diabetes and albuminuria was observed. Further understanding of the links between fat deposition, haematuria and albuminuria is required.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalNephrology
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

Cite this

Hughes, J. T., Maple-Brown, L. J., Thomas, M., Lawton, P. D., Sinha, A., Cass, A., ... Hoy, W. E. (2018). Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults: the eGFR Study. Nephrology, 23(1), 37-45. https://doi.org/10.1111/nep.12956
Hughes, J. T. ; Maple-Brown, L. J. ; Thomas, M. ; Lawton, P. D. ; Sinha, A. ; Cass, A. ; Barzi, F. ; Jones, G. R.D. ; Jerums, G. ; MacIsaac, R. J. ; O'Dea, K. ; Hoy, W. E. / Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults : the eGFR Study. In: Nephrology. 2018 ; Vol. 23, No. 1. pp. 37-45.
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title = "Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults: the eGFR Study",
abstract = "Objective: To describe the detailed associations of albuminuria among a contemporary cohort of Aboriginal and Torres Strait Islander people to inform strategies for chronic kidney disease prevention and management. Methods: A cross-sectional analysis of Indigenous participants of the eGFR Study. Measures: Clinical, biochemical and anthropometric measures were collected (including body-circumferences, blood pressure (BP); triglycerides, HbA1c, liver function tests, creatinine; urine- microscopic-haem, albumin: creatinine ratio (ACR), prescriptions- angiotensin converting enzyme inhibitor or angiotensin receptor II antagonist (ACEI/ARB). Albuminuria and diabetes were defined by an ACR>3.0 mg/mmol, and HbA1c≥48 mmol/mol or prior history respectively. Waist: hip ratio (WHR), and estimated glomerular filtration rate (eGFR) were calculated. ACR was non-normally distributed; a logarithmic transformation was applied (in base 2), with each unit increase in log2-albuminuria representing a doubling of ACR. Results: 591 participants were assessed (71{\%} Aboriginal, 61.6{\%} female, mean age 45.1 years, BMI 30.2 kg/m2, WHR 0.94, eGFR 99.2 ml/min/1.73m2). The overall prevalence of albuminuria, diabetes, microscopic-haem and ACEI/ARB use was 41.5{\%}, 41.5{\%}, 17.8{\%} and 34.7{\%} respectively; 69.3{\%} of adults with albuminuria and diabetes received an ACEI/ARB. Using multivariable linear regression modelling, the potentially modifiable factors independently associated with log2-albuminuria were microscopic-haem, diabetes, WHR, systolic BP, alkaline phosphatase (all positive) and eGFR (inverse). Conclusion: Albuminuria is associated with diabetes, central obesity and haematuria. High ACEI/ARB prescribing for adults with diabetes and albuminuria was observed. Further understanding of the links between fat deposition, haematuria and albuminuria is required.",
author = "Hughes, {J. T.} and Maple-Brown, {L. J.} and M. Thomas and Lawton, {P. D.} and A. Sinha and A. Cass and F. Barzi and Jones, {G. R.D.} and G. Jerums and MacIsaac, {R. J.} and K. O'Dea and Hoy, {W. E.}",
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Hughes, JT, Maple-Brown, LJ, Thomas, M, Lawton, PD, Sinha, A, Cass, A, Barzi, F, Jones, GRD, Jerums, G, MacIsaac, RJ, O'Dea, K & Hoy, WE 2018, 'Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults: the eGFR Study', Nephrology, vol. 23, no. 1, pp. 37-45. https://doi.org/10.1111/nep.12956

Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults : the eGFR Study. / Hughes, J. T.; Maple-Brown, L. J.; Thomas, M.; Lawton, P. D.; Sinha, A.; Cass, A.; Barzi, F.; Jones, G. R.D.; Jerums, G.; MacIsaac, R. J.; O'Dea, K.; Hoy, W. E.

In: Nephrology, Vol. 23, No. 1, 01.01.2018, p. 37-45.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults

T2 - the eGFR Study

AU - Hughes, J. T.

AU - Maple-Brown, L. J.

AU - Thomas, M.

AU - Lawton, P. D.

AU - Sinha, A.

AU - Cass, A.

AU - Barzi, F.

AU - Jones, G. R.D.

AU - Jerums, G.

AU - MacIsaac, R. J.

AU - O'Dea, K.

AU - Hoy, W. E.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: To describe the detailed associations of albuminuria among a contemporary cohort of Aboriginal and Torres Strait Islander people to inform strategies for chronic kidney disease prevention and management. Methods: A cross-sectional analysis of Indigenous participants of the eGFR Study. Measures: Clinical, biochemical and anthropometric measures were collected (including body-circumferences, blood pressure (BP); triglycerides, HbA1c, liver function tests, creatinine; urine- microscopic-haem, albumin: creatinine ratio (ACR), prescriptions- angiotensin converting enzyme inhibitor or angiotensin receptor II antagonist (ACEI/ARB). Albuminuria and diabetes were defined by an ACR>3.0 mg/mmol, and HbA1c≥48 mmol/mol or prior history respectively. Waist: hip ratio (WHR), and estimated glomerular filtration rate (eGFR) were calculated. ACR was non-normally distributed; a logarithmic transformation was applied (in base 2), with each unit increase in log2-albuminuria representing a doubling of ACR. Results: 591 participants were assessed (71% Aboriginal, 61.6% female, mean age 45.1 years, BMI 30.2 kg/m2, WHR 0.94, eGFR 99.2 ml/min/1.73m2). The overall prevalence of albuminuria, diabetes, microscopic-haem and ACEI/ARB use was 41.5%, 41.5%, 17.8% and 34.7% respectively; 69.3% of adults with albuminuria and diabetes received an ACEI/ARB. Using multivariable linear regression modelling, the potentially modifiable factors independently associated with log2-albuminuria were microscopic-haem, diabetes, WHR, systolic BP, alkaline phosphatase (all positive) and eGFR (inverse). Conclusion: Albuminuria is associated with diabetes, central obesity and haematuria. High ACEI/ARB prescribing for adults with diabetes and albuminuria was observed. Further understanding of the links between fat deposition, haematuria and albuminuria is required.

AB - Objective: To describe the detailed associations of albuminuria among a contemporary cohort of Aboriginal and Torres Strait Islander people to inform strategies for chronic kidney disease prevention and management. Methods: A cross-sectional analysis of Indigenous participants of the eGFR Study. Measures: Clinical, biochemical and anthropometric measures were collected (including body-circumferences, blood pressure (BP); triglycerides, HbA1c, liver function tests, creatinine; urine- microscopic-haem, albumin: creatinine ratio (ACR), prescriptions- angiotensin converting enzyme inhibitor or angiotensin receptor II antagonist (ACEI/ARB). Albuminuria and diabetes were defined by an ACR>3.0 mg/mmol, and HbA1c≥48 mmol/mol or prior history respectively. Waist: hip ratio (WHR), and estimated glomerular filtration rate (eGFR) were calculated. ACR was non-normally distributed; a logarithmic transformation was applied (in base 2), with each unit increase in log2-albuminuria representing a doubling of ACR. Results: 591 participants were assessed (71% Aboriginal, 61.6% female, mean age 45.1 years, BMI 30.2 kg/m2, WHR 0.94, eGFR 99.2 ml/min/1.73m2). The overall prevalence of albuminuria, diabetes, microscopic-haem and ACEI/ARB use was 41.5%, 41.5%, 17.8% and 34.7% respectively; 69.3% of adults with albuminuria and diabetes received an ACEI/ARB. Using multivariable linear regression modelling, the potentially modifiable factors independently associated with log2-albuminuria were microscopic-haem, diabetes, WHR, systolic BP, alkaline phosphatase (all positive) and eGFR (inverse). Conclusion: Albuminuria is associated with diabetes, central obesity and haematuria. High ACEI/ARB prescribing for adults with diabetes and albuminuria was observed. Further understanding of the links between fat deposition, haematuria and albuminuria is required.

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U2 - 10.1111/nep.12956

DO - 10.1111/nep.12956

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EP - 45

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JF - Nephrology

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