Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease

Lora Minkova, Sarah Gregory, Rachael I. Scahill, Ahmed Abdulkadir, Christoph P. Kaller, Jessica Peter, Jeffrey D. Long, Julie C. Stout, Ralf Reilmann, Raymund A. Roos, Alexandra Durr, Blair R. Leavitt, Sarah J. Tabrizi, Stefan Klöppel, TRACK-HD Investigators

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanistic insights into brain function, structure and organization in general. While regional atrophy is present at early stages of HD, it is still unclear if both hemispheres are equally affected by neurodegeneration and how the extent of asymmetry affects domain-specific functional decline. Here, we used whole-brain voxel-based analysis to investigate cross-sectional and longitudinal hemispheric asymmetries in grey matter (GM) volume in 56 manifest HD (mHD), 83 pre-manifest HD (preHD), and 80 healthy controls (HC). Furthermore, a regression analysis was used to assess the relationship between neuroanatomical asymmetries and decline in motor and cognitive measures across the disease spectrum. The cross-sectional analysis showed striatal leftward-biased GM atrophy in mHD, but not in preHD, relative to HC. Longitudinally, no net 36-month change in GM asymmetries was found in any of the groups. In the regression analysis, HD-related decline in quantitative-motor (Q-Motor) performance was linked to lower GM volume in the left superior parietal cortex. These findings suggest a stronger disease effect targeting the left hemisphere, especially in those with declining motor performance. This effect did not change over a period of three years and may indicate a compensatory role of the right hemisphere in line with recent functional imaging studies.

Original languageEnglish
Pages (from-to)312-324
Number of pages13
JournalNeuroImage: Clinical
Volume17
DOIs
Publication statusPublished - 2018

Keywords

  • Asymmetries
  • Grey matter volume
  • Huntington's disease
  • MRI
  • VBM

Cite this

Minkova, L., Gregory, S., Scahill, R. I., Abdulkadir, A., Kaller, C. P., Peter, J., ... TRACK-HD Investigators (2018). Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease. NeuroImage: Clinical, 17, 312-324. https://doi.org/10.1016/j.nicl.2017.10.023
Minkova, Lora ; Gregory, Sarah ; Scahill, Rachael I. ; Abdulkadir, Ahmed ; Kaller, Christoph P. ; Peter, Jessica ; Long, Jeffrey D. ; Stout, Julie C. ; Reilmann, Ralf ; Roos, Raymund A. ; Durr, Alexandra ; Leavitt, Blair R. ; Tabrizi, Sarah J. ; Klöppel, Stefan ; TRACK-HD Investigators. / Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease. In: NeuroImage: Clinical. 2018 ; Vol. 17. pp. 312-324.
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abstract = "Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanistic insights into brain function, structure and organization in general. While regional atrophy is present at early stages of HD, it is still unclear if both hemispheres are equally affected by neurodegeneration and how the extent of asymmetry affects domain-specific functional decline. Here, we used whole-brain voxel-based analysis to investigate cross-sectional and longitudinal hemispheric asymmetries in grey matter (GM) volume in 56 manifest HD (mHD), 83 pre-manifest HD (preHD), and 80 healthy controls (HC). Furthermore, a regression analysis was used to assess the relationship between neuroanatomical asymmetries and decline in motor and cognitive measures across the disease spectrum. The cross-sectional analysis showed striatal leftward-biased GM atrophy in mHD, but not in preHD, relative to HC. Longitudinally, no net 36-month change in GM asymmetries was found in any of the groups. In the regression analysis, HD-related decline in quantitative-motor (Q-Motor) performance was linked to lower GM volume in the left superior parietal cortex. These findings suggest a stronger disease effect targeting the left hemisphere, especially in those with declining motor performance. This effect did not change over a period of three years and may indicate a compensatory role of the right hemisphere in line with recent functional imaging studies.",
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author = "Lora Minkova and Sarah Gregory and Scahill, {Rachael I.} and Ahmed Abdulkadir and Kaller, {Christoph P.} and Jessica Peter and Long, {Jeffrey D.} and Stout, {Julie C.} and Ralf Reilmann and Roos, {Raymund A.} and Alexandra Durr and Leavitt, {Blair R.} and Tabrizi, {Sarah J.} and Stefan Kl{\"o}ppel and {TRACK-HD Investigators}",
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Minkova, L, Gregory, S, Scahill, RI, Abdulkadir, A, Kaller, CP, Peter, J, Long, JD, Stout, JC, Reilmann, R, Roos, RA, Durr, A, Leavitt, BR, Tabrizi, SJ, Klöppel, S & TRACK-HD Investigators 2018, 'Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease', NeuroImage: Clinical, vol. 17, pp. 312-324. https://doi.org/10.1016/j.nicl.2017.10.023

Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease. / Minkova, Lora; Gregory, Sarah; Scahill, Rachael I.; Abdulkadir, Ahmed; Kaller, Christoph P.; Peter, Jessica; Long, Jeffrey D.; Stout, Julie C.; Reilmann, Ralf; Roos, Raymund A.; Durr, Alexandra; Leavitt, Blair R.; Tabrizi, Sarah J.; Klöppel, Stefan; TRACK-HD Investigators.

In: NeuroImage: Clinical, Vol. 17, 2018, p. 312-324.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease

AU - Minkova, Lora

AU - Gregory, Sarah

AU - Scahill, Rachael I.

AU - Abdulkadir, Ahmed

AU - Kaller, Christoph P.

AU - Peter, Jessica

AU - Long, Jeffrey D.

AU - Stout, Julie C.

AU - Reilmann, Ralf

AU - Roos, Raymund A.

AU - Durr, Alexandra

AU - Leavitt, Blair R.

AU - Tabrizi, Sarah J.

AU - Klöppel, Stefan

AU - TRACK-HD Investigators

PY - 2018

Y1 - 2018

N2 - Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanistic insights into brain function, structure and organization in general. While regional atrophy is present at early stages of HD, it is still unclear if both hemispheres are equally affected by neurodegeneration and how the extent of asymmetry affects domain-specific functional decline. Here, we used whole-brain voxel-based analysis to investigate cross-sectional and longitudinal hemispheric asymmetries in grey matter (GM) volume in 56 manifest HD (mHD), 83 pre-manifest HD (preHD), and 80 healthy controls (HC). Furthermore, a regression analysis was used to assess the relationship between neuroanatomical asymmetries and decline in motor and cognitive measures across the disease spectrum. The cross-sectional analysis showed striatal leftward-biased GM atrophy in mHD, but not in preHD, relative to HC. Longitudinally, no net 36-month change in GM asymmetries was found in any of the groups. In the regression analysis, HD-related decline in quantitative-motor (Q-Motor) performance was linked to lower GM volume in the left superior parietal cortex. These findings suggest a stronger disease effect targeting the left hemisphere, especially in those with declining motor performance. This effect did not change over a period of three years and may indicate a compensatory role of the right hemisphere in line with recent functional imaging studies.

AB - Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanistic insights into brain function, structure and organization in general. While regional atrophy is present at early stages of HD, it is still unclear if both hemispheres are equally affected by neurodegeneration and how the extent of asymmetry affects domain-specific functional decline. Here, we used whole-brain voxel-based analysis to investigate cross-sectional and longitudinal hemispheric asymmetries in grey matter (GM) volume in 56 manifest HD (mHD), 83 pre-manifest HD (preHD), and 80 healthy controls (HC). Furthermore, a regression analysis was used to assess the relationship between neuroanatomical asymmetries and decline in motor and cognitive measures across the disease spectrum. The cross-sectional analysis showed striatal leftward-biased GM atrophy in mHD, but not in preHD, relative to HC. Longitudinally, no net 36-month change in GM asymmetries was found in any of the groups. In the regression analysis, HD-related decline in quantitative-motor (Q-Motor) performance was linked to lower GM volume in the left superior parietal cortex. These findings suggest a stronger disease effect targeting the left hemisphere, especially in those with declining motor performance. This effect did not change over a period of three years and may indicate a compensatory role of the right hemisphere in line with recent functional imaging studies.

KW - Asymmetries

KW - Grey matter volume

KW - Huntington's disease

KW - MRI

KW - VBM

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EP - 324

JO - NeuroImage: Clinical

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