Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (-)-Fasicularin and (-)-Lepadiformine A

James Burnley; Zhen J. Wang; W. Roy Jackson; Andrea J. Robinson

doi:10.1021/acs.joc.7b01135

Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (-)-Fasicularin and (-)-Lepadiformine A

James Burnley, Zhen J. Wang, W. Roy Jackson, Andrea J. Robinson

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

Abstract

A cross-metathesis protocol has been developed to provide facile access to highly hindered trisubstituted α-branched olefins, which when coupled with a cationic azaspirocyclization reaction, generates the marine alkaloids (-)-fasicularin 2 and a pro-forma synthesis of (-)-lepadiformine A 1.

Original language	English
Pages (from-to)	8497-8505
Number of pages	9
Journal	The Journal of Organic Chemistry
Volume	82
Issue number	16
DOIs	https://doi.org/10.1021/acs.joc.7b01135
Publication status	Published - 18 Aug 2017

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10.1021/acs.joc.7b01135

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title = "Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (-)-Fasicularin and (-)-Lepadiformine A",

abstract = "A cross-metathesis protocol has been developed to provide facile access to highly hindered trisubstituted α-branched olefins, which when coupled with a cationic azaspirocyclization reaction, generates the marine alkaloids (-)-fasicularin 2 and a pro-forma synthesis of (-)-lepadiformine A 1.",

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Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (-)-Fasicularin and (-)-Lepadiformine A

Abstract

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New metal catalysed tandem routes to nitrogen containing compounds

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Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (-)-Fasicularin and (-)-Lepadiformine A

Abstract

UN SDGs

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New metal catalysed tandem routes to nitrogen containing compounds

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