Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (-)-Fasicularin and (-)-Lepadiformine A

James Burnley, Zhen J. Wang, W. Roy Jackson, Andrea J. Robinson

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14 Citations (Scopus)


A cross-metathesis protocol has been developed to provide facile access to highly hindered trisubstituted α-branched olefins, which when coupled with a cationic azaspirocyclization reaction, generates the marine alkaloids (-)-fasicularin 2 and a pro-forma synthesis of (-)-lepadiformine A 1.

Original languageEnglish
Pages (from-to)8497-8505
Number of pages9
JournalThe Journal of Organic Chemistry
Issue number16
Publication statusPublished - 18 Aug 2017

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