Cross-linked poly(trimethylene carbonate- co - L -lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications

Bronwin L. Dargaville, Cédryck Vaquette, Hui Peng, Firas Rasoul, Yu Qian Chau, Justin J. Cooper-White, Julie H. Campbell, Andrew Keith Whittaker

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Abstract

A series of copolymers of trimethylene carbonate (TMC) and l-lactide (LLA) were synthesized and evaluated as scaffolds for the production of artificial blood vessels. The polymers were end-functionalized with acrylate, cast into films, and cross-linked using UV light. The mechanical, degradation, and biocompatibility properties were evaluated. High TMC polymers showed mechanical properties comparable to human arteries (Young's moduli of 1.2-1.8 MPa and high elasticity with repeated cycling at 10% strain). Over 84 days degradation in PBS, the modulus and material strength decreased gradually. The polymers were nontoxic and showed good cell adhesion and proliferation over 7 days using human mesenchymal stem cells. When implanted into the rat peritoneal cavity, the polymers elicited formation of tissue capsules composed of myofibroblasts, resembling immature vascular smooth muscle cells. Thus, these polymers showed properties which were tunable and favorable for vascular tissue engineering, specifically, the growth of artificial blood vessels in vivo.

Original languageEnglish
Pages (from-to)3856-3869
Number of pages14
JournalBiomacromolecules
Volume12
Issue number11
DOIs
Publication statusPublished - 14 Nov 2011
Externally publishedYes

Cite this

Dargaville, B. L., Vaquette, C., Peng, H., Rasoul, F., Chau, Y. Q., Cooper-White, J. J., Campbell, J. H., & Whittaker, A. K. (2011). Cross-linked poly(trimethylene carbonate- co - L -lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications. Biomacromolecules, 12(11), 3856-3869. https://doi.org/10.1021/bm201291e