Cross-border movement of highly drug-resistant Mycobacterium tuberculosis from papua new guinea to Australia through torres strait protected zone, 2010-2015

Arnold Bainomugisa, Sushil Pandey, Ellen Donnan, Graham Simpson, J’Belle Foster, Evelyn Lavu, Stenard Hiasihri, Emma S. McBryde, Rendi Moke, Steven Vincent, Vitali Sintchenko, Ben J. Marais, Lachlan J.M. Coin, Christopher Coulter

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Abstract

In this retrospective study, we used whole-genome sequencing (WGS) to delineate transmission dynamics, characterize drug-resistance markers, and identify risk factors of transmission among Papua New Guinea residents of the Torres Strait Protected Zone (TSPZ) who had tuberculosis diagnoses during 2010-2015. Of 117 isolates collected, we could acquire WGS data for 100; 79 were Beijing sublineage 2.2.1.1, which was associated with active transmission (odds ratio 6.190, 95% CI 2.221-18.077). Strains were distributed widely throughout the TSPZ. Clustering occurred more often within than between villages (p = 0.0013). Including 4 multidrug-resistant tuberculosis isolates from Australia citizens epidemiologically linked to the TSPZ into the transmission network analysis revealed 2 probable cross-border transmission events. All multidrug-resistant isolates (33/104) belonged to Beijing sublineage 2.2.1.1 and had high-level isoniazid and ethionamide co-resistance; 2 isolates were extensively drug resistant. Including WGS in regional surveillance could improve tuberculosis transmission tracking and control strategies within the TSPZ.

Original languageEnglish
Pages (from-to)406-415
Number of pages10
JournalEmerging Infectious Diseases
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 2019
Externally publishedYes

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