TY - JOUR
T1 - Cross-border movement of highly drug-resistant Mycobacterium tuberculosis from papua new guinea to Australia through torres strait protected zone, 2010-2015
AU - Bainomugisa, Arnold
AU - Pandey, Sushil
AU - Donnan, Ellen
AU - Simpson, Graham
AU - Foster, J’Belle
AU - Lavu, Evelyn
AU - Hiasihri, Stenard
AU - McBryde, Emma S.
AU - Moke, Rendi
AU - Vincent, Steven
AU - Sintchenko, Vitali
AU - Marais, Ben J.
AU - Coin, Lachlan J.M.
AU - Coulter, Christopher
PY - 2019/3
Y1 - 2019/3
N2 - In this retrospective study, we used whole-genome sequencing (WGS) to delineate transmission dynamics, characterize drug-resistance markers, and identify risk factors of transmission among Papua New Guinea residents of the Torres Strait Protected Zone (TSPZ) who had tuberculosis diagnoses during 2010-2015. Of 117 isolates collected, we could acquire WGS data for 100; 79 were Beijing sublineage 2.2.1.1, which was associated with active transmission (odds ratio 6.190, 95% CI 2.221-18.077). Strains were distributed widely throughout the TSPZ. Clustering occurred more often within than between villages (p = 0.0013). Including 4 multidrug-resistant tuberculosis isolates from Australia citizens epidemiologically linked to the TSPZ into the transmission network analysis revealed 2 probable cross-border transmission events. All multidrug-resistant isolates (33/104) belonged to Beijing sublineage 2.2.1.1 and had high-level isoniazid and ethionamide co-resistance; 2 isolates were extensively drug resistant. Including WGS in regional surveillance could improve tuberculosis transmission tracking and control strategies within the TSPZ.
AB - In this retrospective study, we used whole-genome sequencing (WGS) to delineate transmission dynamics, characterize drug-resistance markers, and identify risk factors of transmission among Papua New Guinea residents of the Torres Strait Protected Zone (TSPZ) who had tuberculosis diagnoses during 2010-2015. Of 117 isolates collected, we could acquire WGS data for 100; 79 were Beijing sublineage 2.2.1.1, which was associated with active transmission (odds ratio 6.190, 95% CI 2.221-18.077). Strains were distributed widely throughout the TSPZ. Clustering occurred more often within than between villages (p = 0.0013). Including 4 multidrug-resistant tuberculosis isolates from Australia citizens epidemiologically linked to the TSPZ into the transmission network analysis revealed 2 probable cross-border transmission events. All multidrug-resistant isolates (33/104) belonged to Beijing sublineage 2.2.1.1 and had high-level isoniazid and ethionamide co-resistance; 2 isolates were extensively drug resistant. Including WGS in regional surveillance could improve tuberculosis transmission tracking and control strategies within the TSPZ.
UR - http://www.scopus.com/inward/record.url?scp=85061987366&partnerID=8YFLogxK
U2 - 10.3201/eid2503.181003
DO - 10.3201/eid2503.181003
M3 - Article
C2 - 30789135
AN - SCOPUS:85061987366
SN - 1080-6040
VL - 25
SP - 406
EP - 415
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 3
ER -