Critical slowing down as a biomarker for seizure susceptibility

Matias I. Maturana, Christian Meisel, Katrina Dell, Philippa J. Karoly, Wendyl D’Souza, David B. Grayden, Anthony N. Burkitt, Premysl Jiruska, Jan Kudlacek, Jaroslav Hlinka, Mark J. Cook, Levin Kuhlmann, Dean R. Freestone

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Abstract

The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit critical slowing down, a warning signal preceding many critical transitions in dynamical systems. Using long-term intracranial electroencephalography (iEEG) recordings from fourteen patients with focal epilepsy, we monitored key signatures of critical slowing down prior to seizures. The metrics used to detect critical slowing down fluctuated over temporally long scales (hours to days), longer than would be detectable in standard clinical evaluation settings. Seizure risk was associated with a combination of these signals together with epileptiform discharges. These results provide strong validation of theoretical models and demonstrate that critical slowing down is a reliable indicator that could be used in seizure forecasting algorithms.

Original languageEnglish
Article number2172
Number of pages12
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 1 May 2020

Cite this

Maturana, M. I., Meisel, C., Dell, K., Karoly, P. J., D’Souza, W., Grayden, D. B., Burkitt, A. N., Jiruska, P., Kudlacek, J., Hlinka, J., Cook, M. J., Kuhlmann, L., & Freestone, D. R. (2020). Critical slowing down as a biomarker for seizure susceptibility. Nature Communications, 11(1), [2172]. https://doi.org/10.1038/s41467-020-15908-3