Critical need for clarity in polymyxin B dosing

Nikolas J. Onufrak, Gauri G Rao, Alan Forrest, Jason M Pogue, Marc H. Scheetz, Roger L Nation, Jian Li, Keith S Kaye

Research output: Contribution to journalLetterOtherpeer-review

5 Citations (Scopus)

Abstract

We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC24) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CLCR) of 80 ml/min (n = 5; mean CLCR, 90.0 ± 12.5 ml/min; mean AUC24, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC24, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CLCR threshold values of <60and <40 ml/min yielded similar results.
Original languageEnglish
Article numbere00208
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number5
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • Pharmacodynamics
  • Pharmacokinetics
  • Polymyxin B

Cite this

Onufrak, N. J., Rao, G. G., Forrest, A., Pogue, J. M., Scheetz, M. H., Nation, R. L., ... Kaye, K. S. (2017). Critical need for clarity in polymyxin B dosing. Antimicrobial Agents and Chemotherapy, 61(5), [e00208]. https://doi.org/10.1128/AAC.00208-17
Onufrak, Nikolas J. ; Rao, Gauri G ; Forrest, Alan ; Pogue, Jason M ; Scheetz, Marc H. ; Nation, Roger L ; Li, Jian ; Kaye, Keith S. / Critical need for clarity in polymyxin B dosing. In: Antimicrobial Agents and Chemotherapy. 2017 ; Vol. 61, No. 5.
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abstract = "We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC24) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CLCR) of 80 ml/min (n = 5; mean CLCR, 90.0 ± 12.5 ml/min; mean AUC24, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC24, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CLCR threshold values of <60and <40 ml/min yielded similar results.",
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Onufrak, NJ, Rao, GG, Forrest, A, Pogue, JM, Scheetz, MH, Nation, RL, Li, J & Kaye, KS 2017, 'Critical need for clarity in polymyxin B dosing', Antimicrobial Agents and Chemotherapy, vol. 61, no. 5, e00208. https://doi.org/10.1128/AAC.00208-17

Critical need for clarity in polymyxin B dosing. / Onufrak, Nikolas J.; Rao, Gauri G; Forrest, Alan; Pogue, Jason M; Scheetz, Marc H.; Nation, Roger L; Li, Jian; Kaye, Keith S.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 5, e00208, 01.05.2017.

Research output: Contribution to journalLetterOtherpeer-review

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AU - Rao, Gauri G

AU - Forrest, Alan

AU - Pogue, Jason M

AU - Scheetz, Marc H.

AU - Nation, Roger L

AU - Li, Jian

AU - Kaye, Keith S

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N2 - We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC24) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CLCR) of 80 ml/min (n = 5; mean CLCR, 90.0 ± 12.5 ml/min; mean AUC24, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC24, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CLCR threshold values of <60and <40 ml/min yielded similar results.

AB - We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC24) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CLCR) of 80 ml/min (n = 5; mean CLCR, 90.0 ± 12.5 ml/min; mean AUC24, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC24, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CLCR threshold values of <60and <40 ml/min yielded similar results.

KW - Pharmacodynamics

KW - Pharmacokinetics

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M3 - Letter

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Onufrak NJ, Rao GG, Forrest A, Pogue JM, Scheetz MH, Nation RL et al. Critical need for clarity in polymyxin B dosing. Antimicrobial Agents and Chemotherapy. 2017 May 1;61(5). e00208. https://doi.org/10.1128/AAC.00208-17