Critical need for clarity in polymyxin B dosing

Nikolas J. Onufrak; Gauri G Rao; Alan Forrest; Jason M Pogue; Marc H. Scheetz; Roger L Nation; Jian Li; Keith S Kaye

doi:10.1128/AAC.00208-17

Critical need for clarity in polymyxin B dosing

Nikolas J. Onufrak, Gauri G Rao, Alan Forrest, Jason M Pogue, Marc H. Scheetz, Roger L Nation, Jian Li, Keith S Kaye

Research output: Contribution to journal › Letter › Other › peer-review

8 Citations (Scopus)

Abstract

We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC₂₄) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CL_CR) of 80 ml/min (n = 5; mean CL_CR, 90.0 ± 12.5 ml/min; mean AUC₂₄, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC₂₄, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CL_CR threshold values of <60and <40 ml/min yielded similar results.

Original language	English
Article number	e00208
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	5
DOIs	https://doi.org/10.1128/AAC.00208-17
Publication status	Published - 1 May 2017

Keywords

Pharmacodynamics
Pharmacokinetics
Polymyxin B

Access to Document

10.1128/AAC.00208-17

Link to publication in Scopus

Cite this

@article{8131232142b44bd9a6d9ca3019ba58d1,

title = "Critical need for clarity in polymyxin B dosing",

abstract = "We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC24) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CLCR) of 80 ml/min (n = 5; mean CLCR, 90.0 ± 12.5 ml/min; mean AUC24, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC24, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CLCR threshold values of <60and <40 ml/min yielded similar results.",

keywords = "Pharmacodynamics, Pharmacokinetics, Polymyxin B",

author = "Onufrak, {Nikolas J.} and Rao, {Gauri G} and Alan Forrest and Pogue, {Jason M} and Scheetz, {Marc H.} and Nation, {Roger L} and Jian Li and Kaye, {Keith S}",

year = "2017",

month = may,

day = "1",

doi = "10.1128/AAC.00208-17",

language = "English",

volume = "61",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "1098-6596",

publisher = "American Society for Microbiology",

number = "5",

}

TY - JOUR

T1 - Critical need for clarity in polymyxin B dosing

AU - Onufrak, Nikolas J.

AU - Rao, Gauri G

AU - Forrest, Alan

AU - Pogue, Jason M

AU - Scheetz, Marc H.

AU - Nation, Roger L

AU - Li, Jian

AU - Kaye, Keith S

PY - 2017/5/1

Y1 - 2017/5/1

N2 - We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC24) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CLCR) of 80 ml/min (n = 5; mean CLCR, 90.0 ± 12.5 ml/min; mean AUC24, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC24, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CLCR threshold values of <60and <40 ml/min yielded similar results.

AB - We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC24) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CLCR) of 80 ml/min (n = 5; mean CLCR, 90.0 ± 12.5 ml/min; mean AUC24, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC24, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CLCR threshold values of <60and <40 ml/min yielded similar results.

KW - Pharmacodynamics

KW - Pharmacokinetics

KW - Polymyxin B

UR - http://www.scopus.com/inward/record.url?scp=85018184132&partnerID=8YFLogxK

U2 - 10.1128/AAC.00208-17

DO - 10.1128/AAC.00208-17

M3 - Letter

AN - SCOPUS:85018184132

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 1098-6596

IS - 5

M1 - e00208

ER -