Critical need for clarity in polymyxin B dosing

Nikolas J. Onufrak, Gauri G Rao, Alan Forrest, Jason M Pogue, Marc H. Scheetz, Roger L Nation, Jian Li, Keith S Kaye

Research output: Contribution to journalLetterOtherpeer-review

8 Citations (Scopus)

Abstract

We read with interest the report by Thamlikitkul et al. describing polymyxin B exposures in 19 adult patients with and without renal insufficiency (1). No significant difference was observed in the dose-normalized 24-h area under the concentration-time curve (AUC24) at steady state between those with normal renal function, defined as an estimated creatinine clearance (CLCR) of 80 ml/min (n = 5; mean CLCR, 90.0 ± 12.5 ml/min; mean AUC24, 28.6 ± 7.0 mg · h/liter) and those with renal insufficiency (n 14; mean CLCR, 40.8 21.8 ml/min; mean AUC24, 29.7 ± 11.2mg · h/liter; P = 0.80). A sensitivity analysis using lower CLCR threshold values of <60and <40 ml/min yielded similar results.
Original languageEnglish
Article numbere00208
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number5
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • Pharmacodynamics
  • Pharmacokinetics
  • Polymyxin B

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