Creutzfeldt-Jakob disease cluster in an Australian rural city

Steven Collins; Alison Boyd; Ashley Fletcher; John Kaldor; Andrew Hill; Stephen Farish; Catriona McLean; Zahid Ansari; Margaret Smith; Colin L. Masters

doi:10.1002/ana.10224

Creutzfeldt-Jakob disease cluster in an Australian rural city

Steven Collins, Alison Boyd, Ashley Fletcher, John Kaldor, Andrew Hill, Stephen Farish, Catriona McLean, Zahid Ansari, Margaret Smith, Colin L. Masters

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.

Original language	English
Pages (from-to)	115-118
Number of pages	4
Journal	Annals of Neurology
Volume	52
Issue number	1
DOIs	https://doi.org/10.1002/ana.10224
Publication status	Published - Jul 2002
Externally published	Yes

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abstract = "Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.",

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AU - Collins, Steven

AU - Boyd, Alison

AU - Fletcher, Ashley

AU - Kaldor, John

AU - Hill, Andrew

AU - Farish, Stephen

AU - McLean, Catriona

AU - Ansari, Zahid

AU - Smith, Margaret

AU - Masters, Colin L.

PY - 2002/7

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N2 - Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.

AB - Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.

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Creutzfeldt-Jakob disease cluster in an Australian rural city

Abstract

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