Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 55 - 60 |
| Number of pages | 6 |
| Journal | Blood |
| Volume | 122 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
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CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus. / Ong, Monique; Wikstrom, Matthew E; Fleming, Peter; Estcourt, Marie J; Hertzog, Paul John; Hill, Geoffrey R; Andoniou, Christopher E; Degli-Esposti, Mariapia A.
In: Blood, Vol. 122, No. 1, 2013, p. 55 - 60.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus
AU - Ong, Monique
AU - Wikstrom, Matthew E
AU - Fleming, Peter
AU - Estcourt, Marie J
AU - Hertzog, Paul John
AU - Hill, Geoffrey R
AU - Andoniou, Christopher E
AU - Degli-Esposti, Mariapia A
PY - 2013
Y1 - 2013
N2 - Major histocompatibility complex class I-restricted T-cell immunity is essential to control infection with cytomegalovirus (CMV), a clinically important virus that causes significant disease in immunocompromised individuals. Cross-presentation is considered the primary mode of antigen presentation to generate protective antiviral CD8+ T-cell immunity. Herpesviruses, including CMV, encode numerous proteins that interfere with direct antigen presentation, leading to the paradigm that T-cell immunity to these pathogens necessitates cross-presentation. However, the antigen presentation requirements needed to generate a protective T-cell response to CMV remain unknown. Here, we show that a fully functional antiviral CD8+ T-cell response can be generated in a system where cross-presentation is shut down by pretreatment with CpG. Notably, in this setting, CD8+ T cells demonstrate accelerated control of infection, and organ pathology is limited. These data indicate that protective antiviral T-cell immunity to CMV is generated by direct presentation and can be enhanced by pretreatment with CpG.
AB - Major histocompatibility complex class I-restricted T-cell immunity is essential to control infection with cytomegalovirus (CMV), a clinically important virus that causes significant disease in immunocompromised individuals. Cross-presentation is considered the primary mode of antigen presentation to generate protective antiviral CD8+ T-cell immunity. Herpesviruses, including CMV, encode numerous proteins that interfere with direct antigen presentation, leading to the paradigm that T-cell immunity to these pathogens necessitates cross-presentation. However, the antigen presentation requirements needed to generate a protective T-cell response to CMV remain unknown. Here, we show that a fully functional antiviral CD8+ T-cell response can be generated in a system where cross-presentation is shut down by pretreatment with CpG. Notably, in this setting, CD8+ T cells demonstrate accelerated control of infection, and organ pathology is limited. These data indicate that protective antiviral T-cell immunity to CMV is generated by direct presentation and can be enhanced by pretreatment with CpG.
UR - http://bloodjournal.hematologylibrary.org/content/122/1/55.full.pdf+html
U2 - 10.1182/blood-2012-12-471227
DO - 10.1182/blood-2012-12-471227
M3 - Article
VL - 122
SP - 55
EP - 60
JO - Blood
JF - Blood
SN - 0006-4971
IS - 1
ER -