TY - JOUR
T1 - COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19
T2 - A Retrospective Cohort Study
AU - de Freitas Paganoti, Cristiane
AU - da Costa, Rafaela Alkmin
AU - Papageorghiou, Aris T.
AU - da Silva Costa, Fabrício
AU - Quintana, Silvana Maria
AU - de Godoi, Luciana Graziela
AU - Jiménez Monroy, Nátaly Adriana
AU - Sacramento Rodrigues, Agatha
AU - Pulcineli Vieira Francisco, Rossana
N1 - Funding Information:
Conflicts of Interest: Cristiane de Freitas Paganoti, Rafaela Alkmin da Costa, Agatha Sacramento Rodrigues, Silvana Maria Quintana, Fabrício da Silva Costa, Luciana Graziela de Godoi, Nátaly Adriana Jiménez Monroy, and Rossana Pulcineli Vieira declare no competing interests. Aris T. Pa-pageorghiou is supported by the Oxford Partnership Comprehensive Biomedical Research Centre with funding from the NIHR Biomedical Research Centre (BRC) funding scheme.
Funding Information:
Funding: This work was supported in whole or in part by the Bill and Melinda Gates Foundation (INV-027961). Under the grant conditions of the foundation, a creative commons attribution 4.0 generic license was assigned to the author’s accepted manuscript version that might arise from this submission. This work was also funded by CNPq (award number: 445881/2020-8) and FAPES (award number: 007/2021). Aris T. Papageorghiou is supported by the Oxford Partnership Comprehensive Biomedical Research Centre with funding from the NIHR Biomedical Research Centre (BRC) funding scheme. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5
Y1 - 2022/5
N2 - The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who be-come infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p < 0.001, p < 0.001 and p < 0.001, respec-tively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS.
AB - The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who be-come infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p < 0.001, p < 0.001 and p < 0.001, respec-tively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS.
KW - COVID-19 vaccines
KW - intensive care unit
KW - intubation
KW - maternal mortality
KW - pregnancy
KW - severe acute respiratory syndrome
UR - http://www.scopus.com/inward/record.url?scp=85130353560&partnerID=8YFLogxK
U2 - 10.3390/vaccines10050749
DO - 10.3390/vaccines10050749
M3 - Article
C2 - 35632505
AN - SCOPUS:85130353560
SN - 2076-393X
VL - 10
JO - Vaccines
JF - Vaccines
IS - 5
M1 - 749
ER -
