The pathophysiology of severe sepsis and septic shock may involve tissue injury by circulating pro-inflammatory and anti-inflammatory molecules ('soluble mediators'). These mediators appear to be mostly water soluble in nature and in the middle molecular range in size (5-55 kiloDaltons (kD)). These properties make them theoretically amenable to removal by continuous extracorporeal blood purification therapy (EBPT). Accordingly, such EBPT has been proposed as an additional therapeutic option (so-called 'adjunctive therapy') in patients with severe sepsis/septic shock.
|Number of pages||8|
|Journal||International Journal of Intensive Care|
|Publication status||Published - 1 Mar 2006|