Coupled plasma filtration adsorption

Rinaldo Bellomo, Ciro Tetta, Alessandra Brendolan, Claudio Ronco

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Both pro-inflammatory and anti-inflammatory mediators participate in the pathogenesis of sepsis and explain the failure of specific therapies to improve survival. Continuous extracorporeal therapies have been proposed as a therapeutic option in sepsis. We have studied the effects of plasma filtration associated with adsorption in patients with septic shock. We have shown that such treatment may lead to improved survival in a rabbit model of sepsis and to improved hemodynamics, reduced norepinephrine dose and restoration of near-to-normal responsiveness of blood leukocytes to endotoxin in humans. It is anticipated that treatment of plasma, as a device modular to conventional hemofiltration, may pave the way to innovative approaches to the extracorporeal treatment of septic patients.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalBlood Purification
Volume20
Issue number3
DOIs
Publication statusPublished - 14 Mar 2002
Externally publishedYes

Keywords

  • Adsorption
  • Critical illness
  • Hemofiltration
  • Intensive care
  • Multi-organ failure
  • Plasma filtration
  • Resins
  • Septic shock
  • Sorbents

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