Coumarin-based fluorescent sensors for zinc(II) and hypochlorite

Margaret Aulsebrook, Bimbil Graham, Michael Raymond Grace, Kellie Louise Tuck

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Two new fluorescent chemosensors have been designed and synthesised through functionalisation of a common 7-aminocoumarin precursor. One sensor features a di(2-picoyl)amine metal ion-binding moiety that allows for selective detection of Zn2+ ions over other common cations in aqueous solution, with the sensor exhibiting a 5.4-fold increase in fluorescence upon Zn2+ binding (limit of detection = 26 nM). The second sensor incorporates an aminophenyl group designed to react with highly reactive oxygen species (hROS). This sensor reacts with ClO− in preference to other ROS, exhibiting a 27-fold increase in fluorescence upon the addition of 150 equivalents of ClO− (limit of detection = 2 μM)
Original languageEnglish
Pages (from-to)798-806
Number of pages9
JournalSupramolecular Chemistry
Volume27
Issue number11-12
DOIs
Publication statusPublished - 2015

Keywords

  • chemosensor
  • coumarin
  • zinc
  • reactive oxygen species
  • hypochlorite

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