Coumarin-based fluorescent sensors for zinc(II) and hypochlorite

Margaret Aulsebrook, Bimbil Graham, Michael Raymond Grace, Kellie Louise Tuck

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Two new fluorescent chemosensors have been designed and synthesised through functionalisation of a common 7-aminocoumarin precursor. One sensor features a di(2-picoyl)amine metal ion-binding moiety that allows for selective detection of Zn2+ ions over other common cations in aqueous solution, with the sensor exhibiting a 5.4-fold increase in fluorescence upon Zn2+ binding (limit of detection = 26 nM). The second sensor incorporates an aminophenyl group designed to react with highly reactive oxygen species (hROS). This sensor reacts with ClO− in preference to other ROS, exhibiting a 27-fold increase in fluorescence upon the addition of 150 equivalents of ClO− (limit of detection = 2 μM)
Original languageEnglish
Pages (from-to)798-806
Number of pages9
JournalSupramolecular Chemistry
Volume27
Issue number11-12
DOIs
Publication statusPublished - 2015

Keywords

  • chemosensor
  • coumarin
  • zinc
  • reactive oxygen species
  • hypochlorite

Cite this

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title = "Coumarin-based fluorescent sensors for zinc(II) and hypochlorite",
abstract = "Two new fluorescent chemosensors have been designed and synthesised through functionalisation of a common 7-aminocoumarin precursor. One sensor features a di(2-picoyl)amine metal ion-binding moiety that allows for selective detection of Zn2+ ions over other common cations in aqueous solution, with the sensor exhibiting a 5.4-fold increase in fluorescence upon Zn2+ binding (limit of detection = 26 nM). The second sensor incorporates an aminophenyl group designed to react with highly reactive oxygen species (hROS). This sensor reacts with ClO− in preference to other ROS, exhibiting a 27-fold increase in fluorescence upon the addition of 150 equivalents of ClO− (limit of detection = 2 μM)",
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author = "Margaret Aulsebrook and Bimbil Graham and Grace, {Michael Raymond} and Tuck, {Kellie Louise}",
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Coumarin-based fluorescent sensors for zinc(II) and hypochlorite. / Aulsebrook, Margaret; Graham, Bimbil; Grace, Michael Raymond; Tuck, Kellie Louise.

In: Supramolecular Chemistry, Vol. 27, No. 11-12, 2015, p. 798-806.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Graham, Bimbil

AU - Grace, Michael Raymond

AU - Tuck, Kellie Louise

PY - 2015

Y1 - 2015

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KW - chemosensor

KW - coumarin

KW - zinc

KW - reactive oxygen species

KW - hypochlorite

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