Cost-effectiveness analysis of HLA-B*5801 testing in preventing allopurinol-induced SJS/TEN in Thai population

Surasak Saokaew, Tassaneeyakul Wichittra, Ratree Maenthaisong, Nathorn Chaiyakunapruk

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    Abstract

    Background: Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), caused by allopurinol therapy, are strongly associated with the human leukocyte antigen (HLA), HLA-B 5801. Identification of HLA-B 5801 genotype before prescribing allopurinol offers the possibility of avoiding allopurinol-induced SJS/TEN. As there is a paucity of evidence about economic value of such testing, this study aims to determine the cost-effectiveness of HLA-B 5801 testing compared with usual care (no genetic testing) before allopurinol administration in Thailand.
    Original languageEnglish
    Article numbere94294
    Number of pages9
    JournalPLoS ONE
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - 2014

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