Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function

Stephen Walsh; Keith Siew; Fatemeh Afsari; Maneera Al-Jaber; Noah Allen; Mohammed Al-Maadheed; Selin Altinok; Shehbeel Arif; Nourdine Bah; Sergio E Baranzini; Peter Barker; Afshin Beheshti; Elizabeth Blaber; Samuel Border; Valery Boyko; Jessica Broni-Tabi; Keith A. Burling; Robert Campbell; Margareth Cheng-Campbell; Chris Cheshire; Lorianna Colon; Sylvain V. Costes; Laura Cubitt; Viola D'Ambrosio; Lovorka Degoricija; Amelia Eisch; Hossein Fazelinia; Nichola Figg; Rebecca Finch; Jonathan Foox; Alison French; Jonathan Galazka; Samrawit Gebre; Peter Gordon; Alessandra Grillo; Nadia Houerbi; Hossein Valipour Kahrood; Fathi Karouia; Frederico Kiffer; JangKeun Kim; Aleksandra Klosinska; Angela Kubik; Han Chung Lee; Yinghui Li; Zhongwang Li; Nicholas Lucarelli; Steven Lynham; Anthony Marullo; Christopher Mason; Irina Matei; Cem Meydan; Sayat Mimar; Vidya Mohamed-Ali; Masafumi Muratani; Ahmed Naglah; Charlotte Nelson; Kevin A. Nestler; Jerome Nicod; Kevin O'Shaughnessy; Lorraine Christine De Oliveira; Leah Oswalt; Eliah Overbey; Vaksha Patel; Laura Ioana Patras; San-huei Polo; María Rodríguez-Lopez; Samuel Rodriques; Candice Roufosse; Omid Sadeghi-Alavijeh; Rebekah Sanchez-Hodge; Lauren M. Sanders; Anindya Sankar; Pinaki Sarder; Jonathan Schisler; Ralf B. Schittenhelm; Annalise Schweickart; Ryan Scott; Dai Shiba; Terry Lim; Willian Silveira; Hubert Slawinski; Scott Smith; Daniel Snell; Julio Sosa; Joel Steele; Marshall Tabetah; Erwin Tanuwidjaya; Akira Uruno; Michael Vaughan; Simon Walker-Samuel; Elizabeth Wan; Masayuki Yamamoto; Xiaoping Yang; Yasmin Yasmin; Sanghee Yun; Hailey Zhang; Zhongquan Dai; Jasminka Zimmermann; Sara Zwart; Eduardo A.C. Almeida; Chutong Zhong

doi:10.21203/rs.3.rs-2982830/v1

Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function

Stephen Walsh
, Keith Siew
, Fatemeh Afsari
, Maneera Al-Jaber
, Noah Allen
, Mohammed Al-Maadheed
, Selin Altinok
, Shehbeel Arif
, Nourdine Bah
, Sergio E Baranzini
, Peter Barker
, Afshin Beheshti
, Elizabeth Blaber
, Samuel Border
, Valery Boyko
, Jessica Broni-Tabi
, Keith A. Burling
, Robert Campbell
, Margareth Cheng-Campbell
, Chris Cheshire

Lorianna Colon, Sylvain V. Costes, Laura Cubitt, Viola D'Ambrosio, Lovorka Degoricija, Amelia Eisch, Hossein Fazelinia, Nichola Figg, Rebecca Finch, Jonathan Foox, Alison French, Jonathan Galazka, Samrawit Gebre, Peter Gordon, Alessandra Grillo, Nadia Houerbi, Hossein Valipour Kahrood, Fathi Karouia, Frederico Kiffer, JangKeun Kim, Aleksandra Klosinska, Angela Kubik, Han Chung Lee, Yinghui Li, Zhongwang Li, Nicholas Lucarelli, Steven Lynham, Anthony Marullo, Christopher Mason, Irina Matei, Cem Meydan, Sayat Mimar, Vidya Mohamed-Ali, Masafumi Muratani, Ahmed Naglah, Charlotte Nelson, Kevin A. Nestler, Jerome Nicod, Kevin O'Shaughnessy, Lorraine Christine De Oliveira, Leah Oswalt, Eliah Overbey, Vaksha Patel, Laura Ioana Patras, San-huei Polo, María Rodríguez-Lopez, Samuel Rodriques, Candice Roufosse, Omid Sadeghi-Alavijeh, Rebekah Sanchez-Hodge, Lauren M. Sanders, Anindya Sankar, Pinaki Sarder, Jonathan Schisler, Ralf B. Schittenhelm, Annalise Schweickart, Ryan Scott, Dai Shiba, Terry Lim, Willian Silveira, Hubert Slawinski, Scott Smith, Daniel Snell, Julio Sosa, Joel Steele, Marshall Tabetah, Erwin Tanuwidjaya, Akira Uruno, Michael Vaughan, Simon Walker-Samuel, Elizabeth Wan, Masayuki Yamamoto, Xiaoping Yang, Yasmin Yasmin, Sanghee Yun, Hailey Zhang, Zhongquan Dai, Jasminka Zimmermann, Sara Zwart, Eduardo A.C. Almeida, Chutong Zhong

Research output: Contribution to specialist publication › Article › Research

Abstract

Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.

We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions.

We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.

Original language	English
Number of pages	22
Volume	2023
Specialist publication	Research Square preprints
DOIs	https://doi.org/10.21203/rs.3.rs-2982830/v1
Publication status	Published - 11 Oct 2023

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.21203/rs.3.rs-2982830/v1Licence: CC BY

Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Siew, K., Nestler, K. A., Nelson, C., D’Ambrosio, V., Zhong, C., Li, Z., Grillo, A., Wan, E. R., Patel, V., Overbey, E., Kim, J. K., Yun, S., Vaughan, M. B., Cheshire, C., Cubitt, L., Broni-Tabi, J., Al-Jaber, M. Y., Boyko, V., Meydan, C. & Barker, P. & 85 others, Arif, S., Afsari, F., Allen, N., Al-Maadheed, M., Altinok, S., Bah, N., Border, S., Brown, A. L., Burling, K., Cheng-Campbell, M., Colón, L. M., Degoricija, L., Figg, N., Finch, R., Foox, J., Faridi, P., French, A., Gebre, S., Gordon, P., Houerbi, N., Valipour Kahrood, H., Kiffer, F. C., Klosinska, A. S., Kubik, A., Lee, H. C., Li, Y., Lucarelli, N., Marullo, A. L., Matei, I., McCann, C. M., Mimar, S., Naglah, A., Nicod, J., O’Shaughnessy, K. M., Oliveira, L. C. D., Oswalt, L., Patras, L. I., Lai Polo, S. H., Rodríguez-Lopez, M., Roufosse, C., Sadeghi-Alavijeh, O., Sanchez-Hodge, R., Paul, A. S., Schittenhelm, R. B., Schweickart, A., Scott, R. T., Choy Lim Kam Sian, T. C., da Silveira, W. A., Slawinski, H., Snell, D., Sosa, J., Saravia-Butler, A. M., Tabetah, M., Tanuwidjaya, E., Walker-Samuel, S., Yang, X., Yasmin, Zhang, H., Godovac-Zimmermann, J., Sarder, P., Sanders, L. M., Costes, S. V., Campbell, R. A. A., Karouia, F., Mohamed-Alis, V., Rodriques, S., Lynham, S., Steele, J. R., Baranzini, S., Fazelinia, H., Dai, Z., Uruno, A., Shiba, D., Yamamoto, M., A.C.Almeida, E., Blaber, E., Schisler, J. C., Eisch, A. J., Muratani, M., Zwart, S. R., Smith, S. M., Galazka, J. M., Mason, C. E., Beheshti, A. & Walsh, S. B., Dec 2024, In: Nature Communications. 15, 1, 20 p., 4923.
Research output: Contribution to journal › Article › Research › peer-review

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Walsh, S., Siew, K., Afsari, F., Al-Jaber, M., Allen, N., Al-Maadheed, M., Altinok, S., Arif, S., Bah, N., Baranzini, S. E., Barker, P., Beheshti, A., Blaber, E., Border, S., Boyko, V., Broni-Tabi, J., Burling, K. A., Campbell, R., Cheng-Campbell, M., ... Zhong, C. (2023). Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function. Research Square preprints, 2023. https://doi.org/10.21203/rs.3.rs-2982830/v1

@misc{c56a672caef34a4c966aeaa46a2162de,

title = "Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function",

abstract = "Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts{\textquoteright} increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.",

author = "Stephen Walsh and Keith Siew and Fatemeh Afsari and Maneera Al-Jaber and Noah Allen and Mohammed Al-Maadheed and Selin Altinok and Shehbeel Arif and Nourdine Bah and Baranzini, \{Sergio E\} and Peter Barker and Afshin Beheshti and Elizabeth Blaber and Samuel Border and Valery Boyko and Jessica Broni-Tabi and Burling, \{Keith A.\} and Robert Campbell and Margareth Cheng-Campbell and Chris Cheshire and Lorianna Colon and Costes, \{Sylvain V.\} and Laura Cubitt and Viola D'Ambrosio and Lovorka Degoricija and Amelia Eisch and Hossein Fazelinia and Nichola Figg and Rebecca Finch and Jonathan Foox and Alison French and Jonathan Galazka and Samrawit Gebre and Peter Gordon and Alessandra Grillo and Nadia Houerbi and \{Valipour Kahrood\}, Hossein and Fathi Karouia and Frederico Kiffer and JangKeun Kim and Aleksandra Klosinska and Angela Kubik and Lee, \{Han Chung\} and Yinghui Li and Zhongwang Li and Nicholas Lucarelli and Steven Lynham and Anthony Marullo and Christopher Mason and Irina Matei and Cem Meydan and Sayat Mimar and Vidya Mohamed-Ali and Masafumi Muratani and Ahmed Naglah and Charlotte Nelson and Nestler, \{Kevin A.\} and Jerome Nicod and Kevin O'Shaughnessy and \{De Oliveira\}, \{Lorraine Christine\} and Leah Oswalt and Eliah Overbey and Vaksha Patel and Patras, \{Laura Ioana\} and San-huei Polo and Mar{\'i}a Rodr{\'i}guez-Lopez and Samuel Rodriques and Candice Roufosse and Omid Sadeghi-Alavijeh and Rebekah Sanchez-Hodge and Sanders, \{Lauren M.\} and Anindya Sankar and Pinaki Sarder and Jonathan Schisler and Schittenhelm, \{Ralf B.\} and Annalise Schweickart and Ryan Scott and Dai Shiba and Terry Lim and Willian Silveira and Hubert Slawinski and Scott Smith and Daniel Snell and Julio Sosa and Joel Steele and Marshall Tabetah and Erwin Tanuwidjaya and Akira Uruno and Michael Vaughan and Simon Walker-Samuel and Elizabeth Wan and Masayuki Yamamoto and Xiaoping Yang and Yasmin Yasmin and Sanghee Yun and Hailey Zhang and Zhongquan Dai and Jasminka Zimmermann and Sara Zwart and Almeida, \{Eduardo A.C.\} and Chutong Zhong",

year = "2023",

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doi = "10.21203/rs.3.rs-2982830/v1",

language = "English",

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journal = "Research Square preprints",

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Walsh, S, Siew, K, Afsari, F, Al-Jaber, M, Allen, N, Al-Maadheed, M, Altinok, S, Arif, S, Bah, N, Baranzini, SE, Barker, P, Beheshti, A, Blaber, E, Border, S, Boyko, V, Broni-Tabi, J, Burling, KA, Campbell, R, Cheng-Campbell, M, Cheshire, C, Colon, L, Costes, SV, Cubitt, L, D'Ambrosio, V, Degoricija, L, Eisch, A, Fazelinia, H, Figg, N, Finch, R, Foox, J, French, A, Galazka, J, Gebre, S, Gordon, P, Grillo, A, Houerbi, N, Valipour Kahrood, H, Karouia, F, Kiffer, F, Kim, J, Klosinska, A, Kubik, A, Lee, HC, Li, Y, Li, Z, Lucarelli, N, Lynham, S, Marullo, A, Mason, C, Matei, I, Meydan, C, Mimar, S, Mohamed-Ali, V, Muratani, M, Naglah, A, Nelson, C, Nestler, KA, Nicod, J, O'Shaughnessy, K, De Oliveira, LC, Oswalt, L, Overbey, E, Patel, V, Patras, LI, Polo, S, Rodríguez-Lopez, M, Rodriques, S, Roufosse, C, Sadeghi-Alavijeh, O, Sanchez-Hodge, R, Sanders, LM, Sankar, A, Sarder, P, Schisler, J, Schittenhelm, RB, Schweickart, A, Scott, R, Shiba, D, Lim, T, Silveira, W, Slawinski, H, Smith, S, Snell, D, Sosa, J, Steele, J, Tabetah, M, Tanuwidjaya, E, Uruno, A, Vaughan, M, Walker-Samuel, S, Wan, E, Yamamoto, M, Yang, X, Yasmin, Y, Yun, S, Zhang, H, Dai, Z, Zimmermann, J, Zwart, S, Almeida, EAC & Zhong, C 2023, 'Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function' Research Square preprints, vol. 2023. https://doi.org/10.21203/rs.3.rs-2982830/v1

TY - GEN

T1 - Cosmic Kidney Disease

T2 - The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function

AU - Walsh, Stephen

AU - Siew, Keith

AU - Afsari, Fatemeh

AU - Al-Jaber, Maneera

AU - Allen, Noah

AU - Al-Maadheed, Mohammed

AU - Altinok, Selin

AU - Arif, Shehbeel

AU - Bah, Nourdine

AU - Baranzini, Sergio E

AU - Barker, Peter

AU - Beheshti, Afshin

AU - Blaber, Elizabeth

AU - Border, Samuel

AU - Boyko, Valery

AU - Broni-Tabi, Jessica

AU - Burling, Keith A.

AU - Campbell, Robert

AU - Cheng-Campbell, Margareth

AU - Cheshire, Chris

AU - Colon, Lorianna

AU - Costes, Sylvain V.

AU - Cubitt, Laura

AU - D'Ambrosio, Viola

AU - Degoricija, Lovorka

AU - Eisch, Amelia

AU - Fazelinia, Hossein

AU - Figg, Nichola

AU - Finch, Rebecca

AU - Foox, Jonathan

AU - French, Alison

AU - Galazka, Jonathan

AU - Gebre, Samrawit

AU - Gordon, Peter

AU - Grillo, Alessandra

AU - Houerbi, Nadia

AU - Valipour Kahrood, Hossein

AU - Karouia, Fathi

AU - Kiffer, Frederico

AU - Kim, JangKeun

AU - Klosinska, Aleksandra

AU - Kubik, Angela

AU - Lee, Han Chung

AU - Li, Yinghui

AU - Li, Zhongwang

AU - Lucarelli, Nicholas

AU - Lynham, Steven

AU - Marullo, Anthony

AU - Mason, Christopher

AU - Matei, Irina

AU - Meydan, Cem

AU - Mimar, Sayat

AU - Mohamed-Ali, Vidya

AU - Muratani, Masafumi

AU - Naglah, Ahmed

AU - Nelson, Charlotte

AU - Nestler, Kevin A.

AU - Nicod, Jerome

AU - O'Shaughnessy, Kevin

AU - De Oliveira, Lorraine Christine

AU - Oswalt, Leah

AU - Overbey, Eliah

AU - Patel, Vaksha

AU - Patras, Laura Ioana

AU - Polo, San-huei

AU - Rodríguez-Lopez, María

AU - Rodriques, Samuel

AU - Roufosse, Candice

AU - Sadeghi-Alavijeh, Omid

AU - Sanchez-Hodge, Rebekah

AU - Sanders, Lauren M.

AU - Sankar, Anindya

AU - Sarder, Pinaki

AU - Schisler, Jonathan

AU - Schittenhelm, Ralf B.

AU - Schweickart, Annalise

AU - Scott, Ryan

AU - Shiba, Dai

AU - Lim, Terry

AU - Silveira, Willian

AU - Slawinski, Hubert

AU - Smith, Scott

AU - Snell, Daniel

AU - Sosa, Julio

AU - Steele, Joel

AU - Tabetah, Marshall

AU - Tanuwidjaya, Erwin

AU - Uruno, Akira

AU - Vaughan, Michael

AU - Walker-Samuel, Simon

AU - Wan, Elizabeth

AU - Yamamoto, Masayuki

AU - Yang, Xiaoping

AU - Yasmin, Yasmin

AU - Yun, Sanghee

AU - Zhang, Hailey

AU - Dai, Zhongquan

AU - Zimmermann, Jasminka

AU - Zwart, Sara

AU - Almeida, Eduardo A.C.

AU - Zhong, Chutong

PY - 2023/10/11

Y1 - 2023/10/11

N2 - Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.

AB - Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.

U2 - 10.21203/rs.3.rs-2982830/v1

DO - 10.21203/rs.3.rs-2982830/v1

M3 - Article

SN - 2693-5015

VL - 2023

JO - Research Square preprints

JF - Research Square preprints

ER -

Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function

Abstract

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Research output

Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Cite this