Cosmeceutical therapy: Engaging the repercussions of uvr photoaging on the skin’s circadian rhythm

Camille Keisha Mahendra, Hooi Leng Ser, Priyia Pusparajah, Thet Thet Htar, Lay Hong Chuah, Wei Hsum Yap, Yin Quan Tang, Gokhan Zengin, Siah Ying Tang, Wai Leng Lee, Kai Bin Liew, Long Chiau Ming, Bey Hing Goh

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)


Sunlight is an important factor in regulating the central circadian rhythm, including the modulation of our sleep/wake cycles. Sunlight had also been discovered to have a prominent influence on our skin’s circadian rhythm. Overexposure or prolonged exposure to the sun can cause skin photodamage, such as the formation of irregular pigmentation, collagen degradation, DNA damage, and even skin cancer. Hence, this review will be looking into the detrimental effects of sunlight on our skin, not only at the aspect of photoaging but also at its impact on the skin’s circadian rhythm. The growing market trend of natural-product-based cosmeceuticals as also caused us to question their potential to modulate the skin’s circadian rhythm. Questions about how the skin’s circadian rhythm could counteract photodamage and how best to maximize its biopotential will be discussed in this article. These discoveries regarding the skin’s circadian rhythm have opened up a completely new level of understanding of our skin’s molecular mechanism and may very well aid cosmeceutical companies, in the near future, to develop better products that not only suppress photoaging but remain effective and relevant throughout the day.

Original languageEnglish
Article number2884
Number of pages22
JournalInternational Journal of Molecular Sciences
Issue number5
Publication statusPublished - 1 Mar 2022


  • Apoptosis
  • Circadian rhythm
  • Collagen degradation
  • Cosmetics
  • DNA damage
  • Melatonin
  • Natural product
  • Photoaging
  • Pigmentation
  • Ultraviolet rays

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