Cortisol disrupts the ability of estradiol-17beta to induce the LH surge in ovariectomized ewes

Bree Naomi Pierce, Iain James Clarke, Anne Isabella Turner, Elizabeth Therese Astrid Rivalland, Alan John Tilbrook

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Stress disrupts the preovulatory luteinizing hormone (LH) surge in females, but the mechanisms are unknown. We tested the hypothesis that cortisol compromises the ability of estrogen to induce a preovulatory-like LH surge in ovariectomized ewes in both the breeding and nonbreeding season. Luteinizing hormone surges were induced in ovariectomized ewes by treatment with progesterone followed by a surge-inducing estradiol-17beta (E2) stimulus using a crossover design. The experiment was replicated in the breeding and nonbreeding seasons. Cortisol reduced the incidence of LH surges irrespective of season. Cortisol increased the latency from E2 stimulus to the onset of the surge in the breeding season only and suppressed the LH surge amplitude during both seasons (P
Original languageEnglish
Pages (from-to)202 - 208
Number of pages7
JournalDomestic Animal Endocrinology
Issue number4
Publication statusPublished - 2009

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