Corticosteroids, heart failure, and hypertension: a role for immune cells?

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

Aldosterone and its receptor the mineralocorticoid receptor (MR) are best known for their regulation of fluid and electrolyte homeostasis in epithelial cells. However, it is now clear that MR are also expressed in a broad range of nonepithelial tissues including the cardiovascular system. In the heart and vascular tissues, pathological activation of MR promotes cardiovascular inflammation and remodeling for which there is increasing evidence that macrophages and other immune cells (e.g. T cells and dendritic cells) play a significant role. While the glucocorticoids and their receptors have well-described antiinflammatory actions in immune cells, a role for aldosterone and/or the MR in these cells is largely undefined. Emerging evidence, however, suggests that MR signaling may directly or indirectly promote proinflammatory responses in these immune cells. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on cardiovascular diseases involving inflammation.
Original languageEnglish
Pages (from-to)5692 - 5700
Number of pages9
JournalEndocrinology
Volume153
Issue number12
DOIs
Publication statusPublished - 2012

Cite this

@article{d47c94cc09f94398b8f52d0eacb95369,
title = "Corticosteroids, heart failure, and hypertension: a role for immune cells?",
abstract = "Aldosterone and its receptor the mineralocorticoid receptor (MR) are best known for their regulation of fluid and electrolyte homeostasis in epithelial cells. However, it is now clear that MR are also expressed in a broad range of nonepithelial tissues including the cardiovascular system. In the heart and vascular tissues, pathological activation of MR promotes cardiovascular inflammation and remodeling for which there is increasing evidence that macrophages and other immune cells (e.g. T cells and dendritic cells) play a significant role. While the glucocorticoids and their receptors have well-described antiinflammatory actions in immune cells, a role for aldosterone and/or the MR in these cells is largely undefined. Emerging evidence, however, suggests that MR signaling may directly or indirectly promote proinflammatory responses in these immune cells. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on cardiovascular diseases involving inflammation.",
author = "Jimmy Shen and Young, {Morag J}",
year = "2012",
doi = "10.1210/en.2012-1780",
language = "English",
volume = "153",
pages = "5692 -- 5700",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "Endocrine Society",
number = "12",

}

Corticosteroids, heart failure, and hypertension: a role for immune cells? / Shen, Jimmy; Young, Morag J.

In: Endocrinology, Vol. 153, No. 12, 2012, p. 5692 - 5700.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Corticosteroids, heart failure, and hypertension: a role for immune cells?

AU - Shen, Jimmy

AU - Young, Morag J

PY - 2012

Y1 - 2012

N2 - Aldosterone and its receptor the mineralocorticoid receptor (MR) are best known for their regulation of fluid and electrolyte homeostasis in epithelial cells. However, it is now clear that MR are also expressed in a broad range of nonepithelial tissues including the cardiovascular system. In the heart and vascular tissues, pathological activation of MR promotes cardiovascular inflammation and remodeling for which there is increasing evidence that macrophages and other immune cells (e.g. T cells and dendritic cells) play a significant role. While the glucocorticoids and their receptors have well-described antiinflammatory actions in immune cells, a role for aldosterone and/or the MR in these cells is largely undefined. Emerging evidence, however, suggests that MR signaling may directly or indirectly promote proinflammatory responses in these immune cells. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on cardiovascular diseases involving inflammation.

AB - Aldosterone and its receptor the mineralocorticoid receptor (MR) are best known for their regulation of fluid and electrolyte homeostasis in epithelial cells. However, it is now clear that MR are also expressed in a broad range of nonepithelial tissues including the cardiovascular system. In the heart and vascular tissues, pathological activation of MR promotes cardiovascular inflammation and remodeling for which there is increasing evidence that macrophages and other immune cells (e.g. T cells and dendritic cells) play a significant role. While the glucocorticoids and their receptors have well-described antiinflammatory actions in immune cells, a role for aldosterone and/or the MR in these cells is largely undefined. Emerging evidence, however, suggests that MR signaling may directly or indirectly promote proinflammatory responses in these immune cells. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on cardiovascular diseases involving inflammation.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=23125312

U2 - 10.1210/en.2012-1780

DO - 10.1210/en.2012-1780

M3 - Article

VL - 153

SP - 5692

EP - 5700

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 12

ER -