Corticosteroid receptors, macrophages and cardiovascular disease

Amanda J. Rickard, Morag J. Young

Research output: Contribution to journalReview ArticleResearchpeer-review

67 Citations (Scopus)

Abstract

The mineralocorticoid receptor (MR) and glucocorticoid receptor are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While the glucocorticoids cortisol and corticosterone have well-described anti-inflammatory actions on both recruited and tissue resident macrophages, a role for the mineralocorticoid aldosterone in these cells is largely undefined. Emerging evidence, however, suggests that MR signalling may promote pro-inflammatory effects. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on diseases involving inflammation, with a particular focus on cardiovascular disease.

Original languageEnglish
Pages (from-to)449-459
Number of pages11
JournalJournal of Molecular Endocrinology
Volume42
Issue number6
DOIs
Publication statusPublished - 2009
Externally publishedYes

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