Corticosteroid insensitivity in severe asthma: Significance, mechanisms and aetiology

M. Hew, K F Chung

Research output: Contribution to journalReview ArticleResearchpeer-review

55 Citations (Scopus)

Abstract

Chronic severe asthma remains a challenging clinical problem despite the availability of modern treatments. Relative corticosteroid insensitivity is present in severe asthma and may contribute to continuing disease severity. Advances in the understanding of molecular mechanisms underlying corticosteroid insensitivity may yield new therapeutic targets. Furthermore, aetiological factors for corticosteroid insensitivity have been identified and these may be amenable to modification.

Original languageEnglish
Pages (from-to)323-334
Number of pages12
JournalInternal Medicine Journal
Volume40
Issue number5
DOIs
Publication statusPublished - May 2010
Externally publishedYes

Keywords

  • Aetiology
  • Asthma
  • Drug effect
  • Drug therapy
  • Steroid

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