Corticosteroid insensitivity in severe asthma: Significance, mechanisms and aetiology

M. Hew; K F Chung

doi:10.1111/j.1445-5994.2010.02192.x

Corticosteroid insensitivity in severe asthma: Significance, mechanisms and aetiology

M. Hew, K F Chung

Research output: Contribution to journal › Review Article › Research › peer-review

56 Citations (Scopus)

Abstract

Chronic severe asthma remains a challenging clinical problem despite the availability of modern treatments. Relative corticosteroid insensitivity is present in severe asthma and may contribute to continuing disease severity. Advances in the understanding of molecular mechanisms underlying corticosteroid insensitivity may yield new therapeutic targets. Furthermore, aetiological factors for corticosteroid insensitivity have been identified and these may be amenable to modification.

Original language	English
Pages (from-to)	323-334
Number of pages	12
Journal	Internal Medicine Journal
Volume	40
Issue number	5
DOIs	https://doi.org/10.1111/j.1445-5994.2010.02192.x
Publication status	Published - May 2010
Externally published	Yes

Keywords

Aetiology
Asthma
Drug effect
Drug therapy
Steroid

Access to Document

10.1111/j.1445-5994.2010.02192.x

Cite this

@article{c166f866750e414e9f9b636af16d3056,

title = "Corticosteroid insensitivity in severe asthma: Significance, mechanisms and aetiology",

abstract = "Chronic severe asthma remains a challenging clinical problem despite the availability of modern treatments. Relative corticosteroid insensitivity is present in severe asthma and may contribute to continuing disease severity. Advances in the understanding of molecular mechanisms underlying corticosteroid insensitivity may yield new therapeutic targets. Furthermore, aetiological factors for corticosteroid insensitivity have been identified and these may be amenable to modification.",

keywords = "Aetiology, Asthma, Drug effect, Drug therapy, Steroid",

author = "M. Hew and Chung, {K F}",

year = "2010",

month = may,

doi = "10.1111/j.1445-5994.2010.02192.x",

language = "English",

volume = "40",

pages = "323--334",

journal = "Internal Medicine Journal",

issn = "1444-0903",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Corticosteroid insensitivity in severe asthma

T2 - Significance, mechanisms and aetiology

AU - Hew, M.

AU - Chung, K F

PY - 2010/5

Y1 - 2010/5

N2 - Chronic severe asthma remains a challenging clinical problem despite the availability of modern treatments. Relative corticosteroid insensitivity is present in severe asthma and may contribute to continuing disease severity. Advances in the understanding of molecular mechanisms underlying corticosteroid insensitivity may yield new therapeutic targets. Furthermore, aetiological factors for corticosteroid insensitivity have been identified and these may be amenable to modification.

AB - Chronic severe asthma remains a challenging clinical problem despite the availability of modern treatments. Relative corticosteroid insensitivity is present in severe asthma and may contribute to continuing disease severity. Advances in the understanding of molecular mechanisms underlying corticosteroid insensitivity may yield new therapeutic targets. Furthermore, aetiological factors for corticosteroid insensitivity have been identified and these may be amenable to modification.

KW - Aetiology

KW - Asthma

KW - Drug effect

KW - Drug therapy

KW - Steroid

UR - http://www.scopus.com/inward/record.url?scp=77952732147&partnerID=8YFLogxK

U2 - 10.1111/j.1445-5994.2010.02192.x

DO - 10.1111/j.1445-5994.2010.02192.x

M3 - Review Article

AN - SCOPUS:77952732147

SN - 1444-0903

VL - 40

SP - 323

EP - 334

JO - Internal Medicine Journal

JF - Internal Medicine Journal

IS - 5

ER -

Corticosteroid insensitivity in severe asthma: Significance, mechanisms and aetiology

Abstract

Keywords

Access to Document

Other files and links

Cite this