Cortical serotonin7, 1D and 1F receptors: effects of schizophrenia, suicide and antipsychotic drug treatment

Brian Dean, Geoff Pavey, D S Thomas, Elizabeth Scarr

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Abnormalities in serotonergic function are thought to be important in the pathology of schizophrenia. Postmortem CNS studies suggest that levels of serotonin receptors may be altered in the cortex of subjects with schizophrenia. Seeking to expand this hypothesis we have examined the effect of schizophrenia and antipsychotic drug treatments on the levels of cortical serotonin(7), (1D) and (1F) receptors. There was a significant decrease in the binding of [H-3]SB 269970 to the serotonin(7) receptor in Brodmann s area 9 from subjects with schizophrenia compared to controls (Mean +/- S.E.M.: 8.3 +/- 0.76 vs. 11.0 +/- 0.64 fmol/mg ETE; p <0.05) and an increase in the binding of that radioligand in the cortex of rats treated with haloperidol (p=0.03). There were no significant differences in [H-3]sumatriptan binding to the serotonin(1D) or serotonin(1F) receptor in Brodmann s area 9 from subjects with schizophrenia. There was a significant increase in [H-3]sumatriptan binding to the serotonin(1D) in binding Layer 2 from subjects who had potentially died by suicide that was not present in other binding layers or for the serotonin(1F) or serotonin(7) receptors. There was decrease in [H-3]sumatriptan binding to the serotonin(1D), but not serotonin(1F), receptors across all cortical binding layers in rats treated with haloperidol. These data would be consistent with the hypothesis that decreased levels of serotonin(7) receptors in Brodmann s area 9 may be involved in the pathological processes of schizophrenia and that levels of cortical serotonin(7) and (1D) receptors can be affected by antipsychotic drug treatment. (c) 2006 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)265 - 274
Number of pages10
JournalSchizophrenia Research
Issue number1-3
Publication statusPublished - 2006

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