Cortical morphometry and neural dysfunction in Huntington’s disease: a review

Brendan Tan, Rosita Shishegar, Govinda R. Poudel, Alex Fornito, Nellie Georgiou-Karistianis

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)


Numerous neuroimaging techniques have been used to identify biomarkers of disease progression in Huntington's disease (HD). To date, the earliest and most sensitive of these is caudate volume; however, it is becoming increasingly evident that numerous changes to cortical structures, and their interconnected networks, occur throughout the course of the disease. The mechanisms by which atrophy spreads from the caudate to these cortical regions remains unknown. In this review, the neuroimaging literature specific to T1-weighted and diffusion-weighted magnetic resonance imaging is summarized and new strategies for the investigation of cortical morphometry and the network spread of degeneration in HD are proposed. This new avenue of research may enable further characterization of disease pathology and could add to a suite of biomarker/s of disease progression for patient stratification that will help guide future clinical trials.

Original languageEnglish
Pages (from-to)1406-1419
Number of pages14
JournalEuropean Journal of Neurology
Issue number4
Publication statusPublished - Apr 2021


  • cortical morphometry
  • Huntington's disease
  • network spread hypothesis
  • neuroimaging
  • neuronal dysfunction

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