Cortical excitability and recovery curve analysis in generalized epilepsy

Amy Brodtmann; R. A.L. Macdonell; A. K. Gilligan; J. Curatolo; S. F. Berkovic

doi:10.1212/wnl.53.6.1347

Cortical excitability and recovery curve analysis in generalized epilepsy

Amy Brodtmann, R. A.L. Macdonell, A. K. Gilligan, J. Curatolo, S. F. Berkovic

Research output: Contribution to journal › Article › Research › peer-review

51 Citations (Scopus)

Abstract

Seven untreated patients with idiopathic generalized epilepsy were studied with recovery curve analysis using transcranial magnetic stimulation and compared with 16 controls. Patients had a shorter period of inhibition of the test response following a conditioning stimulus and demonstrated a period of increased facilitation of the test response at interstimulus intervals of 200 to 300 msec, which was similar to the mean interdischarge interval of spike-wave activity on EEG. This provides further evidence of cortical hyperexcitability in idiopathic generalized epilepsy.

Original language	English
Pages (from-to)	1347-1349
Number of pages	3
Journal	Neurology
Volume	53
Issue number	6
DOIs	https://doi.org/10.1212/wnl.53.6.1347
Publication status	Published - 12 Oct 1999
Externally published	Yes

Keywords

Cortical excitability
Idiopathic generalized epilepsy
Recovery curve analysis

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10.1212/wnl.53.6.1347

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AU - Berkovic, S. F.

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AB - Seven untreated patients with idiopathic generalized epilepsy were studied with recovery curve analysis using transcranial magnetic stimulation and compared with 16 controls. Patients had a shorter period of inhibition of the test response following a conditioning stimulus and demonstrated a period of increased facilitation of the test response at interstimulus intervals of 200 to 300 msec, which was similar to the mean interdischarge interval of spike-wave activity on EEG. This provides further evidence of cortical hyperexcitability in idiopathic generalized epilepsy.

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Cortical excitability and recovery curve analysis in generalized epilepsy

Abstract

Keywords

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