Cortical brain stimulation with endovascular electrodes

G. Gerboni; S. E. John; S. M. Ronayne; G. S. Rind; C. N. May; T. J. Oxley; D. B. Grayden; N. L. Opie; Y. T. Wong

doi:10.1109/EMBC.2018.8512971

Cortical brain stimulation with endovascular electrodes

G. Gerboni, S. E. John, S. M. Ronayne, G. S. Rind, C. N. May, T. J. Oxley, D. B. Grayden, N. L. Opie, Y. T. Wong

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

8 Citations (Scopus)

Abstract

Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.

Original language	English
Title of host publication	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Editors	Gregg Suaning, Olaf Dossel
Place of Publication	Danvers MA USA
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	3088-3091
Number of pages	4
ISBN (Electronic)	9781538636466, 9781538636459
ISBN (Print)	9781538636473
DOIs	https://doi.org/10.1109/EMBC.2018.8512971
Publication status	Published - 26 Oct 2018
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2018 - Honolulu, United States of America Duration: 17 Jul 2018 → 21 Jul 2018 Conference number: 40th https://embc.embs.org/2018/ https://ieeexplore.ieee.org/xpl/conhome/8471725/proceeding (Proceedings)

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2018
Abbreviated title	EMBC 2018
Country/Territory	United States of America
City	Honolulu
Period	17/07/18 → 21/07/18
Internet address	https://embc.embs.org/2018/ https://ieeexplore.ieee.org/xpl/conhome/8471725/proceeding (Proceedings)

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10.1109/EMBC.2018.8512971

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Gerboni, G., John, S. E., Ronayne, S. M., Rind, G. S., May, C. N., Oxley, T. J., Grayden, D. B., Opie, N. L., & Wong, Y. T. (2018). Cortical brain stimulation with endovascular electrodes. In G. Suaning, & O. Dossel (Eds.), 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 3088-3091). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2018.8512971

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title = "Cortical brain stimulation with endovascular electrodes",

abstract = "Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.",

author = "G. Gerboni and John, {S. E.} and Ronayne, {S. M.} and Rind, {G. S.} and May, {C. N.} and Oxley, {T. J.} and Grayden, {D. B.} and Opie, {N. L.} and Wong, {Y. T.}",

year = "2018",

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doi = "10.1109/EMBC.2018.8512971",

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editor = "Gregg Suaning and Olaf Dossel",

booktitle = "40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

address = "United States of America",

note = "International Conference of the IEEE Engineering in Medicine and Biology Society 2018, EMBC 2018 ; Conference date: 17-07-2018 Through 21-07-2018",

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Gerboni, G, John, SE, Ronayne, SM, Rind, GS, May, CN, Oxley, TJ, Grayden, DB, Opie, NL & Wong, YT 2018, Cortical brain stimulation with endovascular electrodes. in G Suaning & O Dossel (eds), 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, Institute of Electrical and Electronics Engineers, Danvers MA USA, pp. 3088-3091, International Conference of the IEEE Engineering in Medicine and Biology Society 2018, Honolulu, Hawaii, United States of America, 17/07/18. https://doi.org/10.1109/EMBC.2018.8512971

Cortical brain stimulation with endovascular electrodes. / Gerboni, G.; John, S. E.; Ronayne, S. M. et al.
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. ed. / Gregg Suaning; Olaf Dossel. Danvers MA USA: IEEE, Institute of Electrical and Electronics Engineers, 2018. p. 3088-3091.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AU - John, S. E.

AU - Ronayne, S. M.

AU - Rind, G. S.

AU - May, C. N.

AU - Oxley, T. J.

AU - Grayden, D. B.

AU - Opie, N. L.

AU - Wong, Y. T.

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PY - 2018/10/26

Y1 - 2018/10/26

N2 - Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.

AB - Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.

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BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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PB - IEEE, Institute of Electrical and Electronics Engineers

CY - Danvers MA USA

T2 - International Conference of the IEEE Engineering in Medicine and Biology Society 2018

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ER -

Gerboni G, John SE, Ronayne SM, Rind GS, May CN, Oxley TJ et al. Cortical brain stimulation with endovascular electrodes. In Suaning G, Dossel O, editors, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Danvers MA USA: IEEE, Institute of Electrical and Electronics Engineers. 2018. p. 3088-3091 doi: 10.1109/EMBC.2018.8512971

Cortical brain stimulation with endovascular electrodes

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