Cortical brain stimulation with endovascular electrodes

G. Gerboni, S. E. John, S. M. Ronayne, G. S. Rind, C. N. May, T. J. Oxley, D. B. Grayden, N. L. Opie, Y. T. Wong

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
EditorsGregg Suaning, Olaf Dossel
Place of PublicationDanvers MA USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages3088-3091
Number of pages4
ISBN (Electronic)9781538636466, 9781538636459
ISBN (Print)9781538636473
DOIs
Publication statusPublished - 26 Oct 2018
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2018 - Honolulu, United States of America
Duration: 17 Jul 201821 Jul 2018
Conference number: 40th
https://embc.embs.org/2018/

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2018
Abbreviated titleEMBC 2018
CountryUnited States of America
CityHonolulu
Period17/07/1821/07/18
Internet address

Cite this

Gerboni, G., John, S. E., Ronayne, S. M., Rind, G. S., May, C. N., Oxley, T. J., ... Wong, Y. T. (2018). Cortical brain stimulation with endovascular electrodes. In G. Suaning, & O. Dossel (Eds.), 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 3088-3091). Danvers MA USA: IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2018.8512971
Gerboni, G. ; John, S. E. ; Ronayne, S. M. ; Rind, G. S. ; May, C. N. ; Oxley, T. J. ; Grayden, D. B. ; Opie, N. L. ; Wong, Y. T. / Cortical brain stimulation with endovascular electrodes. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. editor / Gregg Suaning ; Olaf Dossel. Danvers MA USA : IEEE, Institute of Electrical and Electronics Engineers, 2018. pp. 3088-3091
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abstract = "Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.",
author = "G. Gerboni and John, {S. E.} and Ronayne, {S. M.} and Rind, {G. S.} and May, {C. N.} and Oxley, {T. J.} and Grayden, {D. B.} and Opie, {N. L.} and Wong, {Y. T.}",
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Gerboni, G, John, SE, Ronayne, SM, Rind, GS, May, CN, Oxley, TJ, Grayden, DB, Opie, NL & Wong, YT 2018, Cortical brain stimulation with endovascular electrodes. in G Suaning & O Dossel (eds), 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, Institute of Electrical and Electronics Engineers, Danvers MA USA, pp. 3088-3091, International Conference of the IEEE Engineering in Medicine and Biology Society 2018, Honolulu, United States of America, 17/07/18. https://doi.org/10.1109/EMBC.2018.8512971

Cortical brain stimulation with endovascular electrodes. / Gerboni, G.; John, S. E.; Ronayne, S. M.; Rind, G. S.; May, C. N.; Oxley, T. J.; Grayden, D. B.; Opie, N. L.; Wong, Y. T.

40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. ed. / Gregg Suaning; Olaf Dossel. Danvers MA USA : IEEE, Institute of Electrical and Electronics Engineers, 2018. p. 3088-3091.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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AU - Rind, G. S.

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AU - Wong, Y. T.

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N2 - Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.

AB - Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.

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BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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PB - IEEE, Institute of Electrical and Electronics Engineers

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Gerboni G, John SE, Ronayne SM, Rind GS, May CN, Oxley TJ et al. Cortical brain stimulation with endovascular electrodes. In Suaning G, Dossel O, editors, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Danvers MA USA: IEEE, Institute of Electrical and Electronics Engineers. 2018. p. 3088-3091 https://doi.org/10.1109/EMBC.2018.8512971