Cortical Afferents of Area 10 in Cebus Monkeys: Implications for the Evolution of the Frontal Pole

Marcello G.P. Rosa, Juliana G.M. Soares, Tristan A. Chaplin, Piotr Majka, Sofia Bakola, Kimberley A. Phillips, David H. Reser, Ricardo Gattass

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Area 10, located in the frontal pole, is a unique specialization of the primate cortex. We studied the cortical connections of area 10 in the New World Cebus monkey, using injections of retrograde tracers in different parts of this area. We found that injections throughout area 10 labeled neurons in a consistent set of areas in the dorsolateral, ventrolateral, orbital, and medial parts of the frontal cortex, superior temporal association cortex, and posterior cingulate/retrosplenial region. However, sites on the midline surface of area 10 received more substantial projections from the temporal lobe, including clear auditory connections, whereas those in more lateral parts received >90% of their afferents from other frontal areas. This difference in anatomical connectivity reflects functional connectivity findings in the human brain. The pattern of connections in Cebus is very similar to that observed in the Old World macaque monkey, despite >40 million years of evolutionary separation, but lacks some of the connections reported in the more closely related but smaller marmoset monkey. These findings suggest that the clearer segregation observed in the human frontal pole reflects regional differences already present in early simian primates, and that overall brain mass influences the pattern of cortico-cortical connectivity.

Original languageEnglish
Article numberbhy044
Pages (from-to)1473-1495
Number of pages23
JournalCerebral Cortex
Volume29
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • connections
  • frontopolar cortex
  • New World monkey
  • prefrontal cortex
  • superior temporal cortex

Cite this

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title = "Cortical Afferents of Area 10 in Cebus Monkeys: Implications for the Evolution of the Frontal Pole",
abstract = "Area 10, located in the frontal pole, is a unique specialization of the primate cortex. We studied the cortical connections of area 10 in the New World Cebus monkey, using injections of retrograde tracers in different parts of this area. We found that injections throughout area 10 labeled neurons in a consistent set of areas in the dorsolateral, ventrolateral, orbital, and medial parts of the frontal cortex, superior temporal association cortex, and posterior cingulate/retrosplenial region. However, sites on the midline surface of area 10 received more substantial projections from the temporal lobe, including clear auditory connections, whereas those in more lateral parts received >90{\%} of their afferents from other frontal areas. This difference in anatomical connectivity reflects functional connectivity findings in the human brain. The pattern of connections in Cebus is very similar to that observed in the Old World macaque monkey, despite >40 million years of evolutionary separation, but lacks some of the connections reported in the more closely related but smaller marmoset monkey. These findings suggest that the clearer segregation observed in the human frontal pole reflects regional differences already present in early simian primates, and that overall brain mass influences the pattern of cortico-cortical connectivity.",
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Cortical Afferents of Area 10 in Cebus Monkeys : Implications for the Evolution of the Frontal Pole. / Rosa, Marcello G.P.; Soares, Juliana G.M.; Chaplin, Tristan A.; Majka, Piotr; Bakola, Sofia; Phillips, Kimberley A.; Reser, David H.; Gattass, Ricardo.

In: Cerebral Cortex, Vol. 29, No. 4, bhy044, 01.04.2019, p. 1473-1495.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Cortical Afferents of Area 10 in Cebus Monkeys

T2 - Implications for the Evolution of the Frontal Pole

AU - Rosa, Marcello G.P.

AU - Soares, Juliana G.M.

AU - Chaplin, Tristan A.

AU - Majka, Piotr

AU - Bakola, Sofia

AU - Phillips, Kimberley A.

AU - Reser, David H.

AU - Gattass, Ricardo

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