Cortical afferents and myeloarchitecture distinguish the medial intraparietal area (MIP) from neighboring subdivisions of the macaque cortex

Sophia Bakola, Lauretta Passarelli, Tony Huynh, Daniele Impieri, Katrina H. Worthy, Patrizia Fattori, Claudio Galletti, Kathleen J. Burman, Marcello G.P. Rosa

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

The parietal reach region (PRR) in the medial bank of the macaque intraparietal sulcus has been a subject of considerable interest in research aimed at the development of braincontrolled prosthetic arms, but its anatomical organization remains poorly characterized. We examined the anatomical organization of the putative PRR territory based on myeloarchitecture and retrograde tracer injections. We found that the medial bank includes three areas: an extension of the dorsal subdivision of V6A (V6Ad), the medial intraparietal area (MIP), and a subdivision of area PE (PEip). Analysis of corticocortical connections revealed that both V6Ad and MIP receive inputs from visual area V6; the ventral subdivision of V6A (V6Av); medial (PGm, 31), superior (PEc), and inferior (PFG/PF) parietal association areas; and intraparietal areas AIP and VIP. They also receive long-range projections from the superior temporal sulcus (MST, TPO), cingulate area 23, and the dorsocaudal (area F2) and ventral (areas F4/F5) premotor areas. In comparison with V6Ad, MIP receives denser input from somatosensory areas, the primary motor cortex, and the medial motor fields, as well as from visual cortex in the ventral precuneate cortex and frontal regions associated with oculomotor guidance. Unlike MIP, V6Ad receives stronger visual input, from the caudal inferior parietal cortex (PG/Opt) and V6Av, whereas PEip shows marked emphasis on anterior parietal, primary motor, and ventral premotor connections. These anatomical results suggest that MIP and V6A have complementary roles in sensorimotor behavior, with MIP more directly involved in movement planning and execution in comparison with V6A.

Original languageEnglish
Article numbere0344-17.2017
Number of pages19
JournaleNeuro
Volume4
Issue number6
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • Connectivity
  • Grasping
  • Parietal
  • Primate
  • Reaching
  • Visuomotor integration

Cite this

Bakola, Sophia ; Passarelli, Lauretta ; Huynh, Tony ; Impieri, Daniele ; Worthy, Katrina H. ; Fattori, Patrizia ; Galletti, Claudio ; Burman, Kathleen J. ; Rosa, Marcello G.P. / Cortical afferents and myeloarchitecture distinguish the medial intraparietal area (MIP) from neighboring subdivisions of the macaque cortex. In: eNeuro. 2017 ; Vol. 4, No. 6.
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title = "Cortical afferents and myeloarchitecture distinguish the medial intraparietal area (MIP) from neighboring subdivisions of the macaque cortex",
abstract = "The parietal reach region (PRR) in the medial bank of the macaque intraparietal sulcus has been a subject of considerable interest in research aimed at the development of braincontrolled prosthetic arms, but its anatomical organization remains poorly characterized. We examined the anatomical organization of the putative PRR territory based on myeloarchitecture and retrograde tracer injections. We found that the medial bank includes three areas: an extension of the dorsal subdivision of V6A (V6Ad), the medial intraparietal area (MIP), and a subdivision of area PE (PEip). Analysis of corticocortical connections revealed that both V6Ad and MIP receive inputs from visual area V6; the ventral subdivision of V6A (V6Av); medial (PGm, 31), superior (PEc), and inferior (PFG/PF) parietal association areas; and intraparietal areas AIP and VIP. They also receive long-range projections from the superior temporal sulcus (MST, TPO), cingulate area 23, and the dorsocaudal (area F2) and ventral (areas F4/F5) premotor areas. In comparison with V6Ad, MIP receives denser input from somatosensory areas, the primary motor cortex, and the medial motor fields, as well as from visual cortex in the ventral precuneate cortex and frontal regions associated with oculomotor guidance. Unlike MIP, V6Ad receives stronger visual input, from the caudal inferior parietal cortex (PG/Opt) and V6Av, whereas PEip shows marked emphasis on anterior parietal, primary motor, and ventral premotor connections. These anatomical results suggest that MIP and V6A have complementary roles in sensorimotor behavior, with MIP more directly involved in movement planning and execution in comparison with V6A.",
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author = "Sophia Bakola and Lauretta Passarelli and Tony Huynh and Daniele Impieri and Worthy, {Katrina H.} and Patrizia Fattori and Claudio Galletti and Burman, {Kathleen J.} and Rosa, {Marcello G.P.}",
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Bakola, S, Passarelli, L, Huynh, T, Impieri, D, Worthy, KH, Fattori, P, Galletti, C, Burman, KJ & Rosa, MGP 2017, 'Cortical afferents and myeloarchitecture distinguish the medial intraparietal area (MIP) from neighboring subdivisions of the macaque cortex', eNeuro, vol. 4, no. 6, e0344-17.2017. https://doi.org/10.1523/ENEURO.0344-17.2017

Cortical afferents and myeloarchitecture distinguish the medial intraparietal area (MIP) from neighboring subdivisions of the macaque cortex. / Bakola, Sophia; Passarelli, Lauretta; Huynh, Tony; Impieri, Daniele; Worthy, Katrina H.; Fattori, Patrizia; Galletti, Claudio; Burman, Kathleen J.; Rosa, Marcello G.P.

In: eNeuro, Vol. 4, No. 6, e0344-17.2017, 01.11.2017.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Cortical afferents and myeloarchitecture distinguish the medial intraparietal area (MIP) from neighboring subdivisions of the macaque cortex

AU - Bakola, Sophia

AU - Passarelli, Lauretta

AU - Huynh, Tony

AU - Impieri, Daniele

AU - Worthy, Katrina H.

AU - Fattori, Patrizia

AU - Galletti, Claudio

AU - Burman, Kathleen J.

AU - Rosa, Marcello G.P.

PY - 2017/11/1

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N2 - The parietal reach region (PRR) in the medial bank of the macaque intraparietal sulcus has been a subject of considerable interest in research aimed at the development of braincontrolled prosthetic arms, but its anatomical organization remains poorly characterized. We examined the anatomical organization of the putative PRR territory based on myeloarchitecture and retrograde tracer injections. We found that the medial bank includes three areas: an extension of the dorsal subdivision of V6A (V6Ad), the medial intraparietal area (MIP), and a subdivision of area PE (PEip). Analysis of corticocortical connections revealed that both V6Ad and MIP receive inputs from visual area V6; the ventral subdivision of V6A (V6Av); medial (PGm, 31), superior (PEc), and inferior (PFG/PF) parietal association areas; and intraparietal areas AIP and VIP. They also receive long-range projections from the superior temporal sulcus (MST, TPO), cingulate area 23, and the dorsocaudal (area F2) and ventral (areas F4/F5) premotor areas. In comparison with V6Ad, MIP receives denser input from somatosensory areas, the primary motor cortex, and the medial motor fields, as well as from visual cortex in the ventral precuneate cortex and frontal regions associated with oculomotor guidance. Unlike MIP, V6Ad receives stronger visual input, from the caudal inferior parietal cortex (PG/Opt) and V6Av, whereas PEip shows marked emphasis on anterior parietal, primary motor, and ventral premotor connections. These anatomical results suggest that MIP and V6A have complementary roles in sensorimotor behavior, with MIP more directly involved in movement planning and execution in comparison with V6A.

AB - The parietal reach region (PRR) in the medial bank of the macaque intraparietal sulcus has been a subject of considerable interest in research aimed at the development of braincontrolled prosthetic arms, but its anatomical organization remains poorly characterized. We examined the anatomical organization of the putative PRR territory based on myeloarchitecture and retrograde tracer injections. We found that the medial bank includes three areas: an extension of the dorsal subdivision of V6A (V6Ad), the medial intraparietal area (MIP), and a subdivision of area PE (PEip). Analysis of corticocortical connections revealed that both V6Ad and MIP receive inputs from visual area V6; the ventral subdivision of V6A (V6Av); medial (PGm, 31), superior (PEc), and inferior (PFG/PF) parietal association areas; and intraparietal areas AIP and VIP. They also receive long-range projections from the superior temporal sulcus (MST, TPO), cingulate area 23, and the dorsocaudal (area F2) and ventral (areas F4/F5) premotor areas. In comparison with V6Ad, MIP receives denser input from somatosensory areas, the primary motor cortex, and the medial motor fields, as well as from visual cortex in the ventral precuneate cortex and frontal regions associated with oculomotor guidance. Unlike MIP, V6Ad receives stronger visual input, from the caudal inferior parietal cortex (PG/Opt) and V6Av, whereas PEip shows marked emphasis on anterior parietal, primary motor, and ventral premotor connections. These anatomical results suggest that MIP and V6A have complementary roles in sensorimotor behavior, with MIP more directly involved in movement planning and execution in comparison with V6A.

KW - Connectivity

KW - Grasping

KW - Parietal

KW - Primate

KW - Reaching

KW - Visuomotor integration

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